8-羟基脱氧鸟苷在早产儿喂养不耐受中的表达及意义

摘要

目的：探讨8-羟基脱氧鸟苷(8-OHdG)在早产儿喂养不耐受患者中的表达和意义。方法将98例早产儿分为喂养不耐受组(48例)和对照组(50例)，收集外周血和尿液，采用ELISA方法检测8-OHdG的表达。结果喂养不耐受组早产儿外周血8-OHdG，第1、7、14天尿8-OHdG的表达明显高于对照组，差异有统计学意义(P<0.05)。结论应激(DNA氧化损伤)可能参与了早产儿喂养不耐受的发病，应激可能是早产儿喂养不耐受的发病机制之一；8-OHdG是评估早产儿喂养不耐受的参考指标。%Objective To explore the expression and significance of 8-Hydroxy-2’-deoxyguanine (8-OHdG) in preterm infant with feeding intolerance. Methods 98 cases of preterm infant were divided into feeding intolerance group (48 cases) and control group (50 cases),expression of 8-OHdG in peripheral blood and urine were measured by ELISA kit between feeding intolerance group and control group. Results 8-OHdG levels in peripheral blood and in urine at day 1,7,14 in feeding intolerance group was higher than that of control group,the difference was significant (P<0.05). Con-clusion DNA oxidative injury might implicate in the pathogenesis of feeding intolerance in preterm infants,stress may be involved in feeding intolerance of preterm infants. 8-OHdG might be a useful parameter for monitoring feeding intol-erance in preterm infant.