促肝细胞生长素治疗慢性病毒性肝炎的效果分析

摘要

目的：探讨促肝细胞生长素治疗慢性病毒性肝炎的临床效果。方法抽取本院2012年2月~2014年2月收治的76例慢性病毒性肝炎患者，将其分为对照组与治疗组，每组38例。对照组采用常规综合对症治疗，治疗组在常规治疗基础上加用促肝细胞生长素。比较两组治疗前后肝功能指标改善幅度、治疗效果、肝功能指标恢复正常时间、用药治疗总时间以及药物不良反应发生率等。结果治疗后两组总胆红素(TBiL)、丙氨酸氨基转移酶(ALT)水平均较治疗前降低，差异有统计学意义(P<0.05)；且治疗组低于对照组，两组间差异有统计学意义(P<0.05)。治疗组总有效率为89.5%，高于对照组的68.4%，差异有统计学意义(P<0.05)。治疗组肝功能指标恢复正常时间及用药治疗总时间均短于对照组，差异有统计学意义(P<0.05)。治疗组药物不良反应发生率为2.6%，低于对照组的21.1%，差异有统计学意义(P<0.05)。结论促肝细胞生长素治疗慢性病毒性肝炎的效果显著，可使肝功能指标在较短时间内恢复正常，缩短药物治疗时间。%Objective To study the clinical effect of hepatocyte growth-promoting factors in the treatment of chronic viral hepatitis. Methods 76 cases of patients with chronic viral hepatitis in our hospital from February 2012 to Febru-ary 2014 were selected,and were divided into control group and treatment group,38 cases in each group.The conven-tional comprehensive hepatitis treatment was given to the control group,hepatocyte growth-promoting factors was taken to the treatment group based on the conventional treatment.The improvement of liver function before and after treat-ment,the clinical efficacy,the time of liver function returned to normal,the total time of drug treatment and the incidence of adverse drug reactions were observed. Results After treatment,TBiL and ALT of two groups decreased compared with before treatment,the difference was significant (P<0.05);and TBiL and ALT of treatment group was lower than that of control group,the difference was significant (P<0.05).The total effective rate of treatment group was 89.5%,higher than 68.4% of control group,the difference was significant (P<0.05).The time of liver function returned to normal,the total time of drug treatment in the treatment group was shorter than that in the control group,the difference was significant (P<0.05).The incidence of adverse drug reaction in the treatment group was 2.6%,lower than 21.1% in the control group,the difference was significant (P<0.05). Conclusion The clinical effect of hepatocyte growth-promoting factors in treatment of chronic viral hepatitis is very obvious,can push the liver function return to normal in a shorter time,shorten the drug treatment period.