富血小板血浆与透明质酸钠治疗膝骨关节炎的效果比较

摘要

Objective To compare the clinical effects of platelet-rich plasma (PRP) and sodium hyaluronate (SH) in the treatment of knee osteoarthritis.Methods A total of 80 patients with knee osteoarthritis who were hospitalized in our hospital from March 2016 to May 2017 were divided into PRP group and SH group according to random number table,40 cases in each group.PRP group was injected with PRP in the joint cavity,and the SH group was treated with SH in the joint cavity.They were performed once a week for 5 times.Both groups were provided with wax,microwave,and ultrasound therapies. The western ontario and mcmaster universities osteoarthritis index scale (WOMAC) and visual analogue scale (VAS) were evaluated for effects before treatment,just after therapy,and 3 and 6 months after treatment during follow up visits. The radiographic results of knee joints using magnetic resonance imaging were compared before and 6 months after treatment.Results The WOMAC score and VAS score were significantly lower in the two groups after treatment than those before treatment(P＜0.05).The scores in the PRP group was lower than those in the SH group just after therapy,3 and 6 months after treatment,with statistical differences (P＜0.05).The improvement rate in the PRP group was better than that in the SH group after magnetic resonance imaging detection,with a significant difference (P＜0.05).Conclusion Both PRP and SH are effective in the treatment of knee osteoarthritis,and the effect in the PRP is more remarkable.%目的 比较富血小板血浆(PRP)及透明质酸钠(SH)治疗膝骨关节炎的临床效果.方法 选取2016年3月～2017年5月在我院住院的80例膝骨关节炎患者,按照随机数字表法分为PRP组和SH组,每组各40例.PRP组行PRP 关节腔注射,SH组行SH 关节腔注射,均每周1次,共5次.两组均配合蜡疗、微波治疗及超声波治疗.于治疗前、治疗后、治疗后3、6个月随访并应用膝骨关节炎评分量表(western ontario and mcmaster universities osteoar thritis index,WOMAC)及视觉模拟评分法(visual analogue score,VAS)进行疗效评估,治疗前及治疗后6个月行膝关节磁共振检查比较影像学结果.结果 在WOMAC 评分及VAS 评分方面,两组治疗后均低于治疗前,差异有统计学意义(P＜0.05);治疗结束后、治疗后3、6个月比较,PRP组低于SH组,差异均有统计学意义(P＜0.05).磁共振检查结果显示,PRP组好转率高于SH组,差异有统计学意义(P＜0.05).结论 PRP 与SH 治疗膝骨关节炎均有较好的效果,但PRP 疗效更加显著.