血浆脑钠素和同型半胱氨酸在急性冠状动脉综合征中的临床意义

摘要

Objective To investigate the clinical effect of BNP and Hcy in the ACS. Methods A total of 107 patients with ACS selected from October 2012 to May 2014 in our hospital were retrospectively analyzed and considered them as the ACS group, the patients were again divided into AMI group (n=50), UA group (n=57), and selected 55 healthy subjects who come to the hospital for physical examination as the same period as the ACS group patients and considered them as the control group, levels of BNP and Hcy in ACS group and the control group, AMI group and UA group were detected, and analyzed the correlation of two adexes. Results BNP and Hcy levels of ACS group, AMI group and UA group were significantly higher than the control group, the difference was statistically significant (P<0.05). BNP levels of AMI group were significantly higher than the UA group, the difference was statistically significant (P<0.05), ACS patients' plasma BNP levels were significantly positively related to Hcy levels (P<0.05). Conclusion The more severity of the disease in patients with ACS, BNP and Hcy levels are also higher, positive correlation between them. Combined detection and treatment of plasma BNP and forecasting, assessment of prognosis in acute coronary syndrome Hcy has important significance.%目的：探讨BNP及Hcy在ACS中的临床作用。方法回顾性分析2012年10月~2014年5月在我院就诊的107例ACS患者，将其作为ACS组，将患者再次分为AMI组(n=50)，UA组(n=57)，选取与ACS组患者同期来医院进行健康体检的健康对象55例作为对照组，比较ACS组、对照组、AMI组及UA组BNP、Hcy水平，并分析两者之间的相关性。结果 ACS组、AMI组及UA组BNP、Hcy水平均显著高于对照组，差异有统计学意义(P<0.05)。AMI组BNP水平显著高于UA组，差异有统计学意义(P<0.05)，ACS组患者血浆BNP水平与Hcy水平呈明显正相关(P<0.05)。结论ACS患者的病情程度越严重，BNP、Hcy水平也越高，二者呈正相关。联合检测血浆BNP及Hcy对急性冠状动脉综合征的预测及治疗、预后的评估均具有重要的意义。