支气管哮喘急性发作期患者白细胞介素（IL-17）及超敏C反应蛋白的水平变化及临床意义

摘要

目的：探讨支气管哮喘急性发作期患者白细胞介素（简称IL-17）及超敏C反应蛋白（hs-CRP）的水平变化及临床意义。方法选择90例哮喘急性发作期患者为研究对象，从哮喘急性发作期患者中随机选择46例患者作为哮喘缓解期组，选择48例健康人群为对照组，对比三组血清IL-17、hs-CRP水平，比较哮喘急性发作期患者治疗前后血清IL-17、hs-CRP水平，分析血清IL-17、hs-CRP水平与患者肺功能的关系。结果三组患者的血清hs-CRP、IL-17水平存在显著差异（P=0.0000）；急性发作期组患者的血清hs-CRP、IL-17水平明显高于缓解期组、对照组（P<0.01）；缓解期组患者的血清hs-CRP、IL-17水平高于对照组（P<0.01）。治疗后哮喘急性发作期患者的血清hs-CRP、IL-17水平明显低于治疗前（P<0.01）。血清hs-CRP、IL-17水平与FEV1占预计值%呈负相关；血清hs-CRP、IL-17水平与FEV1/FVC呈负相关；血清hs-CRP、IL-17水平与ACT呈正相关。结论哮喘急性发作期患者血清IL-17、hs-CRP水平明显增高。哮喘患者血清IL-17、hs-CRP水平与肺功能关系密切。%Objective To study change and clinical significance of IL-17 and hypersensitive c-reactive protein level of bronchial asthma patients with acute episodes. Methods A total of 90 cases of asthma patients with acute phase were selected as the research objects of this study. 46 patients in asthma patients with acute episodes were randomly select-ed as asthma remission group. 48 cases of healthy crowd were selected as control group. Serum IL-17 and hs-CRP lev-els in three groups were compared. Serum IL-17 and hs-CRP levels of asthma patients with acute phase before and af-ter treatment were compared. Relationship between serum IL-17 and hs-CRP levels with pulmonary function in pa-tients were analyzed. Results Serum hs-CRP and IL-17 levels of three groups of patients had significant difference (P=0.0000); Acute phase serum hs-CRP and IL-17 levels of patients were obviously higher than that of remission group and the control group (all P <0.01); Serum hs-CRP and IL-17 levels of patients in remission group were higher than the control group(P<0.01). After treatment serum hs CRP, IL-17 levels of asthma patients with acute phase significant-ly lower than before treatment (P<0.01). Serum hs-CRP, IL-17 levels negatively correlated with FEV1 % of expected value. Serum hs-CRP, IL-17 level negatively correlated with FEV1/FVC. Serum hs-CRP, IL-17 levels were positively related with the ACT. Conclusion IL-17, hs-CRP levels of asthma patients with acute phase serum increased signifi-cantly. Asthma patients' serum hs-CRP, IL-17 levels closely related to pulmonary function.