目的：探讨精神分裂症一级亲属认知功能损害程度和范围，制定合理认知行为干预方案。方法前瞻性选取省立同德医院精神科收治的108例确诊为精神分裂症患者作为患者组，同期选择患者一级亲属108例作为亲属组，另选择健康志愿者108例作为正常组，对比分析三组入选者精神分裂症认知功能成套检测-共识版(MC-CB)检测结果，并据此制定针对性的认知干预措施。结果 MCCB10项分测检验中除言语流畅性外其余9项得分三组间差异均有统计学意义(P<0.05)，亲属组和正常组除持续操作能力和言语流畅性外其余8项得分差异均有统计学意义(P<0.05)，亲属组和患者组在空间广度、符号编码、迷宫、持续操作能力差异有统计学意义(P<0.05)。结论精神分裂症患者一级亲属普遍存在认知功能障碍，合理的认知行为干预能有效改善患者的认知功能水平，提高生存质量。%Objective To analyze the first degree relatives of schizophrenia cognitive function damage degree and range, and make reasonable cognitive behavior intervention program. Methods Prospective selected 108 patients in Palit Provincial Hospital who were diagnosed with schizophrenia as the patient group, selected the same period first-degree relatives of patients with 108 cases as the kinship group, another 108 healthy volunteers were recruited to the normal group, compare and analyze the detection results of cognitive function of schizophrenia complete sets of test ing-consensus Version (MCCB) between the three groups and accordingly develope targeted cognitive interventions. Results Of all the 10 test of MCCB, the difference in verbal fluency between three groups was not significant (P>0.05),the remaining nine scores all had statistically significant difference(P<0.05)among three groups. There were sta-tistically significant differences(P<0.05) in all eight scores except continuous operational capability and verbal fluency between kin group and normal group,the differences in the spatial extent,symbol coding, maze,continuous operation ability were significant(P<0.05) between kin group and patients group. Conclusion First-degree relatives of patients with schizophrenia prevalence of cognitive impairment,cognitive behavior reasonable intervention can improve patients cognitive function level,improve the quality of life.
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