不同预注间期对罗库溴铵起效时间的影响

摘要

Objective To investigate the effects of different pre injection interval on rocuronium onset time. Methods A total of 92 patients who were done general anesthesia hypogastrium operation were selected. According to random digits table method,they were divided into group A,group B,group C and group D,with 23 patientes in each group. All pa-tients were injected atropine, group A, group B and group C were all intravenous driped rocuronium in advance.They were respectively intravenous driped rocuronium after one minute, two minutes, three minutes. Group D were intra-venous driped isometric normal saline,they were intravenous driped rocuronium 3 min after injection of isometric nor-mal saline. The changes of mean arterial pressure, heart rate at different time points, and the T1 value,TOF value,on-set time,condition assessment of trachea cannula and adverse reaction of patients were compared among four groups. Results The mean arterial pressure at T2, T3 in group A, group B,group C was significantly lower than that at T2, T3 in group D(P<0.05). But mean arterial pressure and the heart rate in group C was significantly lower than that in group A and group B (P<0.05). The T1 value,TOF value,onset time in group B,group C were significantly lower than those in group D (P<0.05),The T1 value,TOF value,onset time in C group were significantly lower than those in group A and group B (P<0.05). Proportion of good of tracheal intubation assessment in group A, group B and group C was significantly higher than that in group D. Proportion of good in C group was significantly higher than that in group A, group B (P<0.05). There were no obvious breath scant and adverse reaction etc. Conclusion We should take endotracheal intubation anesthesia as far as possible to choose pre injection interval by 3 minutes, for patients with done general anesthesia hypogastrium operation.%目的：探讨不同预注间期对罗库溴铵起效时间的影响。方法选择全麻下腹部手术治疗的患者92例,根据随机数字表法将患者分为A组、B组、C组和D组,各组23例。所有患者注射阿托品,A组、B组、C组均预先静脉滴注罗库溴铵,分别注射完毕后1 min、2 min、3 min后静脉注射罗库溴铵,D组静脉滴注等体积生理盐水,注射完毕后3 min静注罗库溴铵。比较四组患者平均动脉压、心率在不同时间点变化情况和T1值、TOF值、起效时间、气管插管条件评估及不良反应发生情况。结果 A组、B组、C组平均动脉压、心率在T2、T3均明显低于D组(P<0.05),而C组平均动脉压、心率在T2、T3均明显低于A组、B组(P<0.05)；B组、C组的T1值、TOF值、起效时间均明显低于D组(P<0.05),C组T1值、TOF值、起效时间均明显低于A组、B组(P<0.05)；A组、B组、C组气管插管评估优的比例明显高于D组,C组优的比例明显高于A组、B组(P<0.05)；四组均无明显的呼吸困难、吞咽困难等严重不良反应情况发生。结论对于全麻腹部手术患者尽可能选择预注间期3 min进行气管插管麻醉。