Objective To investigate the influence on patients' serum cytokines by different type of gastric cancer D2 radical operation, to provide reference for selecting surgical method of gastric cancer D2 radical operation. Methods 152 patients with advanced gastric cancer who were received and cured in surgery department of our hospital from May 2010 to Jun 2013 were collected. According to surgical method,they were divided into laparotomy group(n=74)and la-paroscopic group(n=78),the change of tumor necrosis factor(TNF)-α, interleukin(IL)-6,IL-10 of peritoneal lavage fluid were compared between two groups after opening abdomen and before closing abdomen. Results The TNF-α、IL-6、IL-10 level of peritoneal lavage fluid after opening abdomen had no significant differences between two groups,the TNF-α、IL-6 level before closing abdomen in laparoscopic group were significantly lower than those in laparotomy group,the IL-10 level was significantly higher than that in laparotomy group(P<0.05). Conclusion Compared with la-parotomy gastric cancer D2 radical operation,laparoscopic D2 radical operation can significantly reduce postoperative TNF-α、IL-6 level, increase IL-10 level, reduce abdominal local inflammation, promote recovery body function, so as to improve patient's prognosis .%目的：探讨胃癌D2根治术不同术式对患者血清细胞因子的影响，为胃癌D2根治术术式选择提供参考。方法收集2010年5月~2013年6月我院外科收治的进展期胃癌患者152例，根据手术方法分为开腹组（n=74）和腹腔镜组（n=78）。比较两组患者开腹后、关腹前的腹腔冲洗液肿瘤坏死因子（TNF-α）、白介素（IL）-6、IL-10水平的变化。结果两组患者开腹后腹腔冲洗液TNF-α、IL-6、IL-10水平无明显差异，关腹前腹腔镜组TNF-α、IL-6水平明显低于开腹组，IL-10水平明显高于开腹组（P<0.05）。结论与开腹胃癌D2根治术相比，腹腔镜胃癌D2根治术能明显降低患者术后TNF-α、IL-6，增加IL-10水平，降低腹腔局部炎症反应，促进机体功能的恢复，从而改善患者预后。
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