血尿酸和S 100 β蛋白与急性脑梗死的相关性研究

摘要

Objective To investigate the changes of serum S 100 β protein and uric acid(UA) content in patients with acute cerebral infarction(ACI). Methods The level of serum S 100 βand UA in 54 patients with ACI and 21 normal controls were measured, The changes of S 100 β and UA were compared among patients of different pathogenetic condition and infarction area. The correlation analysis between S 100 β and UA was also made. ResultsCompared with control group,the levels of serum S 100 β and UA in patients with ACI increased significantly (all P <0.01 ). The level of serum S 100 β and UA increased with the score of neurofunction detection and infarction area. Conclusions The S 100 β protein and UA protein can be indexes of predicting the neurofunction of ACT and a combination with each other provides a higher clinical significance.%目的 探讨急性脑梗死患者血清S 100 β蛋白和尿酸含量变化的意义及其机制.方法 测定54例急性脑梗死患者及21例正常人血清S 100 β蛋白和尿酸的含量,观察比较急性脑梗死患者在不同病情、不同梗死面积时的血清S 100 β蛋白和尿酸含量变化.结果 急性脑梗死患者血清S 100 β蛋白浓度[(0.458±0.109)μg/L]和尿酸浓度[(415.3±41.5)μmol/L]浓度明显高于对照组[分别为(0.057±0.024)μg/L和(261.5±30.1) μmol/L],差异有统计学意义(P<0.01).随着神经功能缺损程度的加重和梗死面积的增大,血清S 100 β和尿酸含量亦明显升高.结论 S 100 β蛋白与尿酸一样可作为预测急性脑梗死患者病情严重程度及预后的生化指标,二者相结合进行评价意义更大.