六味地黄丸联合激素治疗系统性红斑狼疮疗效观察

摘要

目的 探讨六味地黄丸联合激素治疗系统性红斑狼疮(SLE)的疗效.方法 60例患者按信封法随机分为2组,30例给予醋酸泼尼松足量(1 ms/kg)治疗(单纯激素治疗组).30例(激素联合中药治疗组)给予醋酸泼尼松足量1 mg/(kg·d)的同时,口服六味地黄丸6 g/次,2次/d.直至激素减量至每日15 mg、患者无明显肾阴虚症状时,逐渐减少六味地黄丸的剂量,改为6 g/次,每日1次13服.分别在患者入院当时及用药后2,4、8周检测血清TC、TG、HDL-C和载脂蛋白A_1、B浓度.观察患者是否出现向心性肥胖,满月脸、紫纹、水牛背等症状.结果 激素联合中药治疗组患者用药后2,4、8周血清TC、TG、载脂蛋白B浓度较前不同程度降低(F=22.88、4.84、90.66,均P<0.05),HDL-C、载脂蛋白A1较前有所升高(F=10.02、4.50,均P<0.05)).30例单纯激素治疗组患者血清TC、TG、载脂蛋白B浓度逐渐升高(F=21.14、5.01、68.73,均P<0.05),HDL-C、载脂蛋白A1较前有所下降(F=9.98、5.69,均P<0.05).激素联合中药治疗组TC、TG、载脂蛋白B、载脂蛋白A1及HDL-C均较单纯激素组改善明显(均P<0.05).单纯激素治疗组向心性肥胖、满月脸、紫纹、水牛背等症状一直持续到激素停用2个月之后.结论 六味地黄丸联合激素治疗SLE简便易行,安全有效.%Objective To study the effeet of Liu Wei Di Huang Wan combined with hormone for systemic lupus erythematosus(SLE).Methods Sixty patients were randomly divided into 2 groups:30 were treated with prednisolone acetate in sufficient quantifies(1 ms/kg)treatment(hormone therapy alone group,group A)and 30 cases(Hormones and traditional Chinese medicine treatment group,Group B)were given the full amount of prednisone acetate(1 ms/ks)treatment and oral Liuweidihuangwan 6 g/times,2 times/d at the same time.The serum cholesterol,triglyceride,hish-density lipoprotein cholesterol and apolipoprotein A1,B concentration at the time of hospitalization and 2,4,8 weeks after treatment were detected.Centripetal obesity,moon face,purple stripes,buffalo hump and other symptoms were observed.Results Two,four,eight weeks after treatment,Cholesterol,Triglyeride,Carry lipoprotein B in group B decreased(F=22.88,4.841,90.66)and hish density lipeprotein,Carry lipoprotein A1 increased(F:10.02,4.501).Cholesterol,T riglyeride,Carry lipoprotein B in group A increased (F=21.14,5.014,68.73)and high density lipeprotein,Carry lipeproteinA1 decreased(F=9.984,5.689).All indicators of group B were improved more significantly than those of group A(all P<0.05).Condusion Liuwei Dihuangwan combinationed with hormone is simple,easy and safe for treatment of SLE.