子(癎)前期患者血浆前列环素12与视网膜血管病变的研究

摘要

Objective To analyze the relationship between the senun prostacyclin( PGI2 ) level and the vascular lesion degree of retina in pre-eclampsia patients. Methods Serum level of PGI2 was detected by radio-immu-no analysis method in 38 cases of pre-eclampsia before and after delivery, and then was compared with that in 30 cases of healthy late gestational women. Meanwhile, the vascular lesion of retina was checked in all 38 cases and the correlation between its degree and the serum PGI2 level (before and after delivery) was analyzed. Results In the pre-eclampsia groups, serum level of PGI2 either before or after delivery was lower than that in the healthy gestational women group( 133.3 ±111.6 ng/L vs 238.4 ± 102. 2 ng/L, 146.1 ± 54. 0 ng/L vs 245.9 ± 95. 4 ng/L, P < 0.01 for all). A significant negative relationship was detected between the serum levels of PGI2 before delivery and the vascular lesion degree of retina in pre-eclampsia patients(r=-0.631, P<0.05). Conclusions There is a close relationship between the serum levels of PGI2 and blood vessel lesion of retina in patients with pre-eclampsia. The decrease of serum PGI2 may play important role in occurring and deterioration of retina blood vessel lesions.%目的 观察子(癎)前期患者血浆前列环素12(PGh)水平与眼底视网膜血管病变程度的关系.方法 采用放射免疫法检测38例子(癎)前期患者(研究组)和30例正常足月妊娠待产孕妇(对照组)产前、产后血浆PGI2水平,同时专人检查其眼底视网膜病变情况,分析2组孕妇产前、产后血浆PGI2水平的差异及其与视网膜血管改变之间的关系.结果 研究组产前及产后血浆PGI2:水平均明显低于对照组[(133.3±111.6)ng/L比(238.4±102.2)ng/L,(146.1±54.0)ng/L比(245.9±95.4)ng/L,均P<0.01].研究组眼底视网膜病变分期与产前血浆PGI2水平呈负相关(r=-0.644,P<0.05).结论 血浆PGI2水平与子(癎)前期的病情和眼底病变有密切关系,PGI2水平下降在妊娠期高血压病患者的视网膜病变发生发展过程中发挥重要作用.