2型糖尿病患者糖化血红蛋白达标与血脂的相关性研究

摘要

Objective To understand the influence of lipid by up to standard type 2 diabet glycated hemogloobin and to discuss the relationship of saccharide metabolism and lipid metabolism.Methods Ninty-five patients with type 2 diabetes in Shanghai Yin-line Community were divided into two groups(HbAlc≤6.5 and HbAlc>7.0),the level of blood lipid in the two groups were compared.Meanwhile,95 patients in the glycosylated hemo globin and the corre8ponding blood were analyzed. Results TC,TG,HDL-C,LDL-C of substandard group [(5.42±1.04)mmoL/L vs(5.06±1.07)mmol/L,(2.90±1.59)mmol/L vs(2.03 ±1.48)mmol/L,(1.09±0.14)mmoL/L vs(1.05±0.17)mmol/L,(3.16 ±0.58)mmol/L vs(2.92±0.62)mmol/L,respectively J were higher than those in standard group.TG of substandard group was significantly elevated(P<0.05).The standard rate of TC,TG,HDL-C in standard group were higher than those in substandard group[5 cases(14.7%)vs 3 cases(6.4%),17 cases(50.0%)vs 10 cases(22.2%),6 cases(17.6%)vs 3 cases(6.7%),P<0.05].Univariate analy8is showed that HbAlc and TC,TG,LDH-C was positively correlated(r=0.208,0.438,0.222,both P<0.05).Conclusions HbAlc reduction can effectively reduce TC,TG,LDL-C,while the standard of HbAlc can significanty improve the standard rate of TG.Type 2 diabetes should have regular monitoring of glycated hemoglobin and HbAl c should be controlled at normal levels.%目的 了解2型糖尿病患者糖化血红蛋白(HbAlc)达标对血脂的影响,探讨糖脂代谢的关联性.方法 完全随机抽取上海市殷行社区95例2型糖尿病患者的糖化血红蛋白、血脂,按HbAlc≤6.5%和HbAlc≥7.0%分成2组,其中HBAlc达标组34例,HbAlc未达标组45例,比较2组的血脂情况,同时进行HbAlc与血脂的相关性分析.结果 未达标组患者TC,TG,HDL-C,LDL-C明显高于达标组[分别为(5.42±1.04)mmol/L比(5.06±1.07)mmol/L、(2.90 ±1.59)mmol/L比(2.03±1.48)mmol/L、(1.09±0.14)mmol/L比(1.05±0.17)mmol/L、(3.16±0.58)mmol/L比(2.92±0.62)mmol/L],且TG升高有统计学意义(P<0.05).达标组TC,TG,LDH-C达标率明显高于未达标组[分别为5例(14.7%)比3例(6.7%)、17例(50.0%)比10例(22.2%)、6例(17.6%)比3例(6.7%),P<0.05].单因素分析结果表明HbAlc与TC、TG、LDH-C呈正相关(r=0.208、0.438、0.222,均P<0.05).结论 降低HbAlc可有效降低,TC、TG、LDL-C,同时HbAlc达标可以明显提高TG的达标率,2型糖尿病患者应定期监测HbAlc,控制HbAlc在正常水平.