目的 分析并对比进口紫杉醇与国产紫杉醇治疗上皮性卵巢癌的近期疗效与副作用.方法 回顾性分析我院2006年1月至2010年12月收治的59例上皮性卵巢癌患者的临床资料,其中经进口紫杉醇(泰素)治疗的患者18例(进口紫杉醇组),经国产紫杉醇治疗的患者41例(国产紫杉醇组),对2组患者的年龄、病理类型、临床分期、是否合并腹水及肠管或肝脾转移情况、治疗方法(常规治疗或是先期化疗),及治疗总有效率和无瘤生存期以及患者的骨髓抑制情况进行对比.结果 2组患者年龄、病理类型、临床分期、合并转移情况及治疗方法差异均无统计学意义(P＞0.05).进口紫杉醇组治疗后总有效率为94.4％(17/18),其中完全缓解(CR) 13例,部分缓解(PR)4例,进展(PD)1例；国产紫杉醇组总有效率95.1％(39/41),其中CR 29例,PR 10例,PD 2例；2组总有效率比较差异无统计学意义(P＞0.05).进口紫杉醇组和国产紫杉醇组无瘤生存期差异无统计学意义(P＞0.05).进口紫杉醇组发生0度骨髓抑制为5例,Ⅰ度0例,Ⅱ度7例,Ⅲ度3例,Ⅳ度3例；国产紫杉醇组0度骨髓抑制为10例,Ⅰ度为3例,Ⅱ度14例,Ⅲ度11例,Ⅳ度3例.2组骨髓抑制发生情况差异无统计学意义(P＞0.05).结论 进口紫杉醇与国产紫杉醇在治疗上皮性卵巢癌的近期疗效与不良反应方面无差异.%Objective To analyze and compare the curative effect and side effects of imported and domestic paclitaxel on epithelial ovarian cancer patients.Methods A retrospective analysis of 59 epithelial ovarian cancer patients from January 2006 to December 2010 was conducted.18 patients was treated by imported paclitaxel(imported paclitaxel group) and other patients underwent domestic paclitaxel(domestic paclitaxel group).The age,pathological types,staging,complications,treatment methods,treatment efficiency,progression-free survial time and bone marrow suppression were compared.Results No statistical difference was observed in their age,pathological types,staging,complications,treatment methods (P ＞ 0.05).The total effective rate in imported paclitaxel group and domestic paclitaxel group was 94.4％ (17/18) and 95.1％ (39/41) without significant difference (P ＞ 0.05).There was no difference of bone marrow suppression between two groups (P ＞ 0.05).Conclusion Thereis a similar effect between the domestic and imported paclitaxel in treatment of epithelial ovarian cancer.
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