目的 探讨小儿智力糖浆治疗儿童脑外伤后遗症的临床效果.方法 选择2010年6月至2013年6月吉林市儿童医院诊断为脑外伤后遗症患儿141例,根据入院先后顺序,按单双号将患儿分为对照组(68例)和治疗组(73例).治疗组口服小儿智力糖浆,对照组口服吡拉西坦.共治疗3个月.比较2组疗效、不良反应率以及复发率;通过比较2组患儿治疗前后Conners儿童行为问卷父母用量表评价儿童行为,采用简易智能精神状态检查量表(MMSE)评价神经功能.结果 ①对照组和治疗组总有效率分别为76.5％(52/68)和89.0％(65/73),组间差异有统计学意义(P＜0.05).对照组和治疗组不良反应发生率分别为38.2％(26/68)和4.1％(3/73),组间差异有统计学意义(P＜0.05).治疗6个月随访观察,对照组和治疗组复发率分别为13.2％(9/68)和4.1％ (3/73),组间差异有统计学意义(P＜0.05).②在品行、学习、心身、冲动多动、焦虑、多动指数等儿童行为方面,对照组和治疗组治疗后[(1.04±0.31)、(1.01±0.29)分,(1.3±0.5)、(1.3±0.5)分,(0.7±0.5)、(0.6±0.3)分,(1.0±0.4)、(0.9±0.4)分,(0.87±0.25)、(0.91±0.32)分,(1.0±0.4)、(1.1±0.5)分]均较治疗前[(1.32±0.26)、(1.34±0.27)分,(1.8±0.5)、(1.9±0.4)分,(1.3±0.4)、(1.3±0.5)分,(1.5±0.5)、(1.5±0.5)分,(0.65±0.21)、(0.68±0.27)分,(1.6±0.3)、(1.6±0.4)分]明显改善(均P ＜0.05),但各项儿童行为的组间差异均无统计学意义(均P＞0.05).③对照组和治疗组治疗后MMSE总分均高于本组治疗前,治疗前后比较差异均有统计学意义[对照组:(26.9±2.4)分比(20.7±4.7)分,治疗组:(26.0±2.5)分比(20.8±4.6)分,均P＜0.05],但治疗后各项神经功能评分组间差异均无统计学意义(均P＞0.05).结论 小儿智力糖浆有助于改善脑外伤后遗症患儿的儿童行为及神经功能.%Objective To explore the effect of Xiao' er zhili syrup on post-traumatic brain syndrome.Methods A total of 73 cases of children with post-traumatic brain syndrome were treatment group and treated with Xiao'er zhili syrup; 68 cases of children were control groupand treated with acetamidepyrrolidone.The clinical curative effects,adverse reactions ratio and relapse rate were evaluated.Meanwhile,the examination of conners child behavior rating scale for parents and mini-mental state examination(MMSE) were conducted before and after treatment.Results ①The total efficiency of the treatment group and the control group was 76.5％ (52/68) and 89.0％ (65/73) ; the difference between groups was statistically significant (P ＜ 0.05).The incidence of adverse reaction of treatment group and control group was 38.2％ (26/68) and 4.1％ (3/73) ; the difference between groups was statistically significant (P ＜ 0.05).At discharge and 6 months follow-up,the recurrence rate in control group and treatment group was 13.2％ (9/68) and 4.1％ (3/73) ; the difference between groups was statistically significant (P ＜0.05).②After treatment,morality,psychosomatic,impulsive restlessness,anxiety,hyperactivity indices including behaviorin control group and treatment group were[(1.04 ± 0.31) scores,(1.01 ± 0.29) scores ; (1.3 ± 0.5) scores,(1.3 ± 0.5) scores ; (0.7 ± 0.5) scores,(0.6 ± 0.3) scores ; (1.0 ± 0.4) scores,(0.9 ± 0.4) scores ; (0.87 ± 0.25) scores,(0.91 ± 0.32) scores ; (1.0 ± 0.4) scores,(1.1 ± 0.5) scores] significantly improved compared with those before treatment [(1.32 ± 0.26) scores,(1.34 ± 0.27) scores ; (1.8 ±0.5) scores,(1.9 ± 0.4) scores ; (1.3 ± 0.4) scores,(1.3 ± 0.5) scores ; (1.5 ± 0.5) scores,(1.5 ± 0.5)scores;(0.65±0.21) scores,(0.68 ±0.27) scores;(1.6±0.3) scores,(1.6±0.4) scores] (P＜0.05);but there were no significant differences regarding behavior indices between groups (P ＞ 0.05).③MMSE total scores of the treatment group and the control group after treatment were higher than those before treatment ; the difference between groups was statistically significant [control group:(26.9 ± 26.9) scores vs (20.7 ± 4.7)scores,treatment group:(26.0 ± 2.5) scores vs (20.8 ± 4.6) scores,all P ＜ 0.05],but there were no significant differences regarding the nerve function between groups (all P ＞ 0.05).Conclusion Xiao'er zhili syrup is good for treatment of children with post-traumatic brain syndrome in clinic.
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