复方枸橼酸阿尔维林治疗慢性非萎缩性胃炎的效果研究

摘要

目的 观察复方枸橼酸阿尔维林治疗慢性非萎缩性胃炎的效果和不良反应.方法 124例慢性非萎缩性胃炎患者完全随机分为观察组和对照组,各62例.观察组口服雷贝拉唑钠肠溶胶囊(10 mg/次,2次/d)、复方枸橼酸阿尔维林(1粒/次,3次/d),对照组口服雷贝拉唑(10 mg/次,2次/d)、枸橼酸莫沙必利(5 mg/次,3次/d),均用药2周.记录2组治疗前和治疗第2周末各症状评分和症状总积分,并参照各症状评分和症状总积分变化评价疗效.结果 治疗结束后第2周末,观察组各症状评分均较治疗前明显下降(P＜0.05);观察组上腹疼痛、腹胀、嗳气症状评分明显低于对照组[(0.9±0.4)分比(1.6±0.5)分,(0.8±0.4)分比(2.3±0.7)分,(0.80 ±0.19)分比(1.13 ±0.44)分],组间差异有统计学意义(P＜0.05),反酸、上腹不适症状积分的组间差异无统计学意义(均P＞0.05);2组症状总积分均较治疗前下降,观察组治疗后症状总积分明显低于对照组[(4.7±1.2)分比(7.6±1.2)分](P＜0.05).观察组上腹疼痛、腹胀、反酸、嗳气、上腹不适等各症状有效率和总有效率分别为91.7％ (55/60)、94.8％(55/58)、90.3％ (28/31)、91.1％ (41/45)、89.8％ (53/59)、95.0％ (57/60),均高于对照组[82.8％(48/58)、74.1％(43/58)、77.4％(24/31)、72.2％(26/36)、83.0％(49/59)、91.5％(54/59)],差异有统计学意义(均P ＜0.05).2组患者不良反应发生率差异无统计学意义(P＞0.05).结论 复方枸橼酸阿尔维林辅助治疗慢性非萎缩性胃炎,可较好缓解腹痛、消化不良等症状,总有效率较高,不良反应较低.%Objective To discuss the effect of compound alverine citrate treating chronic non-atropmc gastritis and related adverse reaction.Methods Totally 124 cases of chronic non-atrophic gastritis were divided into observation group and control group.Observation group received rabeprazole and compound alverine citrate; control group received rabeprazole and mosapride citrate.All groups received drugs for 2 weeks.Each symptom scores and the total symptom score were evaluated and the efficacy was assessed according to the symptom score and the changes of symptom score.Results After four weeks treatment,each symptom score was decreased significantly in the observation group(P ＜0.05) ; the symptom score was significantly lower than that in the control group.Symptoms scores in abdominal pain,bloating,belching of observation group were reduced significantly compared with control group [(0.9 ± 0.4) scores vs (1.6 ± 0.5) scores,(0.8 ± 0.4) scores vs (2.3 ± 0.7) scores,(0.80 ± 0.19) scores vs (1.13 ± 0.44) scores] (P ＜ 0.05).And there were no significant difference in acid reflux and abdominal between two groups (all P ＞ 0.05).After treatment,two groups' total score of symptoms were decreased; the total symptom score in observation group was significantly lower than that in the control group [(4.7 ± 1.2) scores vs (7.6 ± 1.2) scores] (P ＜ 0.05).The efficiency and the total effective rate in abdominal pain,abdominal distention,acid regurgitation,belching,epigastric discomfort and other symptoms of observation groupwere higher than those in the control group [91.7％ (55/60) vs 82.8％ (48/58),94.8％ (55/58) vs 74.1％ (43/58),90.3 ％ (28/31) vs 77.4％ (24/31),91.1％ (41/45) vs 72.2 ％ (26/36),89.8 ％ (53/59) vs 83.0％ (49/59),95.0％ (57/60) vs 91.5％ (54/59)] (all P ＜ 0.05).There was no significant difference in incidence of related adverse reaction between two groups (P ＞ 0.05).Conclusion Compound alverine citrate treating chronic non-atrophic gastritis is high efficiency and safe.