Objective To evaluate the clinical value of capsule endoscopy in diagnosis of Behcet's disease.Methods Five patients with Behcet's disease and 20 cases with Behcet's disease in literatures who underwent capsule endoscopy were retrospectively analyzed.Results The 25 patients were 20-65 years old (mean 41 years), male 9 case, famale 16 cases.Totally 24 (96.0％) patients had systematic symptoms of Behcet's disease and the rest one was considered to be independent intestinal Behcet's disease.Regarding clinical manifestation, 15 (60.0％) patients had gastrointestinal symptoms such as abdominal pain, diarrhea and melena, even massive hemorrhage or perforation;the patients with esophagus involvement had retrosternal pain;10 (40.0％) patients only complained about merely abdominal discomfort and melena when being asked intentionally.Fifteen patients with gastrointestinal symptoms underwent gastrointestinal endoscopy and colonoscopy;the results showed no abnormal in 9 cases of upper gastrointestinal endoscopy and 9 cases of colonoscopy, showed abnormal which could explain the gastrointestinal symptoms in 4 cases of upper gastrointestinal endoscopy and 4 cases of colonoscopy, showed abnormal which could not explain the gastrointestinal symptoms in 2 cases of upper gastrointestinal endoscopy and 2 cases of colonoscopy.Ten patients with mild digestive symptoms did not undergo gastrointestinal endoscopy and colonoscopy.The results of capsule endoscopy showed different degrees of lesions in all patients.Totally 16.0％ (4/25) lesions located in esophagus, 16.0％ (4/25) located at stomach, 32.0％ (8/25) located at duodenum, 44.0％ (11/25) located at jejunum, 72.0％ (18/25) located at ileum, 48.0％ (12/25) located at ileocecum, 12.0％ (3/25) located at cecum and 8.0％ (2/25) located at rectum.Conclusions The whole digestive tract can be involved in Behcet's disease without specific clinical features.Capsule endoscopy can effectively evaluate lesions of the digestive tract, especially those in small intestine, which is helpful to explain the gastrointestinal symptom and increase the early diagnostic rate and decrease misdiagnosis.%目的 评估胶囊内镜在白塞病诊断中的应用价值.方法 对本院5例与文献报道的20例行胶囊内镜检查的白塞病患者的临床资料进行综合分析.结果 25例白塞病患者中男9例、女16例,年龄20 ～ 65岁,中位年龄为41岁,24例(96.0％)患者有白塞病的系统表现,1例(4.0％)考虑为独立的肠白塞病.临床表现:15例(60.0％)患者有明显消化道症状,以腹痛、腹泻、便血常见,严重者出现大出血、穿孔,食管受累者出现胸痛后疼痛,余10例(40.0％)症状不明显,仅有轻微间断腹痛、便血.内镜下表现:15例消化系统症状明显者均行胃肠镜检查,结果9例胃镜及9例肠镜检查未发现异常,4例胃镜及4例肠镜检查所见异常可解释消化道症状,2例胃镜及2例肠镜异常不能解释症状,10例消化道症状轻微者未行胃肠镜检查;25例胶囊内镜检查结果均提示不同程度病变,病变分布于食管4例(16.0％),胃4例(16.0％),十二指肠8例(32.0％),空肠11例(44.0％),回肠18例(72.0％),回盲部12例(48.0％),结肠3例(12.0％),直肠2例(8.0％).结论 白塞病病变全消化道均可受累,临床表现缺乏特异性,应用胶囊内镜可有效评估全消化道尤其是小肠病变,有助于解释消化系统症状,提高早期肠白塞病的诊断准确率,减少漏诊率.
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