卵巢子宫内膜样癌的临床特点及预后分析

摘要

Objective To explore the clinical feature and prognosis of ovarian endometrioid carcinoma.Methods Totally 42 cases with ovarian endometrioid carcinoma from January 1990 to January 2014 were enrolled in observation group.A totally of 720 cases with ovarian serous or mucinous adenocarcinoma were included in control group.The patients were treated with ovarian cancer staging surgery or ovary tumor rebulking operation plus chemotherapy according to different clinical stages.The clinical features,clinical stage and five-year survival rate were compared between the two groups.Results The clinical features of distention,abdominal pain,irregular vaginal bleeding,medically unfit without any abnormal symptoms had no significant differences between the two groups (P ＞0.05).There were 14 cases (33.3％) with stage Ⅰ,11 cases (26.2％) with stage Ⅱ,13 cases (31.0％) with stage Ⅲ and 4 cases with stage Ⅳ (9.5％) in observation group;there were 57 cases (7.9％) with stage Ⅰ,72 cases (10.0％) with stage Ⅱ and 396 cases (55.0％) with stage Ⅲ and 195 cases (27.1％) with stage Ⅳ in control group;there were significant differences of regarding clinical stages between the two groups (P ＜ 0.05).The five-year survival rate was 59.5 ％ (25/42) in observatiorgroup [stage Ⅰ:85.7％ (12/14),stage Ⅱ:72.7％ (8/11),stage Ⅲ:38.5％ (5/13),stage Ⅳ:0.0％ (0/4)];the five-year survival rate was 33.2％ (239/720) in control group [stage Ⅰ:80.7％ (46/57),stage Ⅱ:68.1％ (49/72),stage Ⅲ:35.9％ (142/396),stage Ⅳ:1.0％ (2/195)];the total five-year survival rate in observation rate were significant higher than that in control group,but not with each stage (P ＞ 0.05).Conclusion Ovarian endometrioid carcinoma has an earlier clinical stages and higher five-year survival rate.%目的 探讨卵巢子宫内膜样癌的临床特点并对其预后进行分析.方法 选择山西省大同市第一人民医院和首都医科大学附属北京妇产医院1990年1月至2014年1月收治的42例卵巢子宫内膜样癌患者作为观察组,将同期收治的720例卵巢浆液性腺癌和卵巢黏液性腺癌患者作为对照组.根据不同临床分期选择卵巢癌分期性手术或肿瘤细胞减灭术及化疗,比较2组的临床表现、临床分期和5年生存率.结果 2组腹胀、腹痛、阴道不规则出血、无明显症状的临床特征比较,差异无统计学意义(P＞0.05).观察组Ⅰ期患者14例(33.3％)、Ⅱ期11例(26.2％)、Ⅲ期13例(31.0％)、Ⅳ期4例(9.5％);对照组Ⅰ期57例(7.9％)、Ⅱ期72例(10.0％)、Ⅲ期396例(55.0％)、Ⅳ期195例(27.1％);2组临床分期比较差异有统计学意义(P＜0.05).治疗后持续随访,观察组5年生存率为59.5％ (25/42),Ⅰ～Ⅳ期分别为85.7％(12/14),72.7％(8/11),38.5％(5/13),0.0％(0/4);对照组5年生存率为33.2％(239/720),其中Ⅰ～Ⅳ期分别为80.7％(46/57),68.1％(49/72),35.9％(142/396),1.0％(2/195);观察组5年生存率明显高于对照组,差异有统计学意义(P＜0.05),但2组各临床分期5年生存率比较,差异无统计学意义(P＞0.05).结论 卵巢子宫内膜样癌早期患者更常见,其5年生存率较高.