Objective To analyze the value of ABO blood group antibody antibody titers in serum of pregnant woman of O-type blood in late pregnancy in predicting neonatal hemolytic disease.Methods Totally 655 pregnant women of O-type blood in late pregnancy from January 2014 to April 2015 underwent detection of ABO blood group antibody antibody titers in serum of pregnant woman;according to the IgG anti-A (B) were divided into5 groups (≤64,128 and ＞64,≤256 and ＞128,≤512 and ＞256,＞512).The three standard tests of hemolytic disease was performed in neonates with neonatal hemolytic disease.The correlation of neonatal hemolytic disease and ABO blood group antibody antibody titers in serum of pregnant woman in late pregnancy was analyzed in 655 neonates.Results There were 103 (15.7％) strongly positive patients in neonatal antibody elution test.There were respectively 5 cases (1.6％,5/307),15 cases (12.6％,15/119),19 cases (26.4％,19/72),28 cases (38.9％,28/72),36 cases (42.4％,36/85) of neonatal hemolytic disease in pregnant women with antibody antibody titers ≤64,≤128 and ＞64,≤256 and ＞128,≤512 and ＞256,＞512,with significant differences between groups (all P ＜ 0.05).The levels of total and indirect bilirubin in neonatal serum decreased with increasing of antibody antibody titer (P ＜ 0.05).Conclusion In pregnant women in late pregnancy,the ABO blood group antibody antibody titer in serum has the clinal significance of monitoring the occurence of neonatal hemolytic disease.%目的 分析0型血孕妇妊娠晚期血清ABO血型抗体滴度对新生儿溶血病的预测价值.方法 选取从2014年1月1日到2015年4月30日期间于江苏省苏州市立医院进行产前检测的O型血孕妇655例作为研究对象,检测其ABO血型抗体滴度,按IgG抗-A(B)滴度分为5组(≤64,≤128且＞64,≤256且＞128,≤512且＞256,＞512),并对发生新生儿溶血病的患儿进行新生儿溶血3项试验检查,观察655名新生儿中新生儿溶血病的发生情况与孕妇妊娠晚期血清ABO血型抗体滴度的关系.结果 新生儿抗体放散试验呈强阳性者103例,占15.7％.孕妇妊娠晚期血清抗体滴度≤64时发生新生儿溶血病者5例(占1.6％,5/307),≤128且＞64时15例(占12.6％,15/119),≤256且＞128时19例(占26.4％,19/72)、≤512且＞256时28例(占38.9％,28/72)、＞512时36例(占42.4％,36/85),两两比较差异均有统计学意义(均P＜0.05).新生儿血清总胆红素、血清间接胆红素均随着抗体滴度的升高而呈递增的趋势,差异均有统计学意义(均P＜0.05).结论 O型血孕妇妊娠晚期血清ABO血型抗体滴度的检测对新生儿溶血病的发生有一定的监测作用,在临床上有一定的指导意义.
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