辅助性T细胞在包虫病中相关作用的研究进展

摘要

Helper T cells (Th cells) exert crucial regulating effect in human immune response against parasites.Echinococcosis,also known as hydatid disease,causes immunological protection and injury with cellular immunity as the predominant reaction.Th cells and related cytokines are hotspots of researches on hydatid disease;the immune escape mechanism of Th1/Th2 cells in echinococcus infection has been proved;emerging reaches focus more on Th9 and Th17 cells,suggesting that there is a potential link between Th9/Th17 cells and the immune response to hydatid disease.This article reviewed advanced progress of Th cells in hydatid disease.%辅助性T细胞(Th细胞)作为免疫应答最重要的调节细胞,在机体的抗寄生虫免疫反应中起着极为关键的作用.包虫病又称棘球蚴病,其免疫机制多为免疫性保护与损伤并存,其中以细胞免疫造成的保护和伤害为主要表现.近年来关于Th细胞及其细胞因子的研究逐渐成为包虫病研究领域的热点,目前对于Th1/Th2细胞在包虫病中免疫逃逸机制的相关研究已经得到公认,新兴的研究多集中在Th9和Th17细胞上,初步揭示了二者在包虫病免疫反应中存在潜在联系.本文对Th细胞在包虫病中相关作用的研究进展进行综述.