295例宫颈病变患者HPV亚型多重感染与宫颈病变的关系

摘要

Objective To study the correlation between multiple papillomavirus(HPV)infection and cervical disease. Methods Using HPV genotyping technology, HPV subtypes were detected in cervical smear or paraffin-embedded cervical tissues samples. Results The total HPV infection rate was 58.98%(174/295). The constituent ratio of varied severity of cervical diseases were significantly different from those only infected high risk or multiple HPV(include high and low risk HPV)group and only infected low risk group(x2=16.801,P < 0.05;x2=11.303,P < 0.05); There was no significant difference between multiple high risk (or multiple low risk) and only high risk (or only low risk) group(x2=7.325,P>0.05;x2=4.362, P>0.05),respectively, while a significant difference was observed in people with only high risk and low risk infected types(x2=16.369, P<0.05). Conclusion The risk of cervical cancer was raised in women infected with high risk HPV subtypes compared with low risk groups,while the severity of cervical diseases was not increased with infected multiple HPV subtypes.%目的：探讨人乳头瘤病毒（HPV）不同亚型多重感染与宫颈病变的关系。方法采用基因芯片技术对手术切除宫颈石蜡组织及液基细胞技术所获宫颈脱落细胞进行基因分型检查，同时检测其宫颈病变程度。结果295例宫颈病变样本总的HPV阳性率为58.98%（174/295）。仅感染高危HPV或高、低混合型HPV组的宫颈病变程度构成比与仅感染低危型HPV组的对应构成比差异有统计学意义（x2=16.801，P＜0.05；x2=11.303，P＜0.05）；多重感染高危或多重低危HPV组分别与单一感染高、低危HPV组之间，其宫颈病变程度的构成比差异无统计学意义（x2=7.325，P＞0.05；x2=4.362，P＞0.05）；单一高、低危亚型之间有统计学差异（x2=16.369，P＜0.05）。结论高危型HPV感染增加了宫颈癌的患病风险，而多重感染并未促进宫颈病变的发展。