Objective To discuss the application situation of prophylactic antibacterial use during perioperative period and to provide objective basis for reasonable application administration of antibacterial drugs. Methods 711 operation cases from 2014 January-2014 May were investigated, the situation of prophylactic antibacterial use during perioperative period was retrospective investigated and statistics analyzed. Results The prophylactic antibacterial use rate during perioperative period was 75.9%. The antibacterial use rate of type I incision was 73.7%. Prophylactic use of antibacterial was mainly a single drug, accounted for 67.8%, the highest frequency application of drug was cefuroxime. Preoperative 2h medication accounted for 63%, 55.4% of the class 1, Ⅱ incision operation preventive medication time > 2d. Conclusion There are unreasonable questions about prophylactic antibacterial use during perioperative period, management effect need to be strengthened, and to improve the rational use of antibacterial.%目的：探讨围术期抗菌药物预防性应用现状，为抗菌药物合理性应用管理提供客观依据。方法调查2014年1~5月出院的711份手术病例，对围术期预防性应用抗菌药物情况进行回顾性调查及统计分析。结果围术期预防用药率为75.9%，其中Ⅰ类切口抗菌药物使用率为73.7%。预防性应用抗菌药物以单一药物为主，占67.8%，孢呋辛应用频数最高。术前2h 用药占63.0％，55.4％的Ⅰ、Ⅱ类切口手术预防用药时间＞2d。结论围术期抗菌药物预防性应用存在不合理问题，需进一步加大管理力度，提高抗菌药物的合理应用。
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