1吡美莫司乳膏联合地奈德乳膏治疗青年成人期特应性皮炎的疗效及生活质量评价

摘要

Objective To investigate the efficacy and life quality evaluation of 1% pimecrolimus cream combined with desonide cream in the treatment of atopic dermatitis in young adults. Methods Sixty-four adults with atopic dermatitis were divided into the observation group and the control group,with 32 patients in each group.The control group was given desonide cream smearing over the afflicted part and the observation group was given combined l%pimecrolimus cream for 3 continuous weeks.The efficacy and skin lesion area,clinical symptom score of itching,and change of life quality DLQI of the two groups were compared. Results In the observation group,the clinical cure rate reached 21.8% and the total effective rate after the treatment reached 90.6%,which were significantly higher than those of the control group respectively(P<0.05). The itching,skin lesion area and total clinical symptom score after the treatment of the observation group were 0.32±0.07, 0.39±0.14 and 1.73±0.26 respectively,which were significantly different from those of the control group(P < 0.05).The observation group had significantly improved scores of symptoms/feeling,leisure activities,work and study, interpersonal relationship,daily activities,treatment influence and total influence compared to the control group after the treatment(P < 0.05). Conclusion In the treatment of atopic dermatitis in young adults,1%pimecrolimus cream combined with desonide cream shows accurate efficacy and good safety and can obviously improve the patients'clinical symptoms,thus improves the patients'life quality,which is worthy of promotion and application.%目的：探讨1%吡美莫司乳膏联合地奈德乳膏治疗青年成人期特应性皮炎的疗效及生活质量评价。方法64例成人期特应性皮炎患者分为观察组和对照组各32例，对照组予地奈德乳膏涂患处，观察组联合l%吡美莫司乳膏，连续治疗3周。比较两组的疗效及皮损面积、瘙痒的临床症状评分、生活质量DLQI 的变化。结果观察组临床治愈率达21.8%、观察组治疗后的总有效率达90.6%，分别显著高于对照组（P＜0.05）。观察组患者治疗后瘙痒、皮损面积及临床症状总积分分比为0.32±0.07、0.39±0.14、1.73±0.26，与对照组治疗后比较，差异有统计学意义（P＜0.05）。观察组患者治疗后的症状/感觉、休闲活动、工作学习、人际关系、日常活动、治疗的影响及总影响各项评分均较对照组明显改善（P＜0.05）。结论 l%吡美莫司乳膏联合地奈德乳膏治疗青年成人期特应性皮炎的疗效确切，安全性好，可以明显改善患者的临床症状，从而提高患者的生活质量，值得推广和应用。