Objective To investigate the inhibitory effect of sodium butyrate on the growth of breast cancer cells MCF-7. Methods Breast cancer MCF-7 cells were cultured to logarithmic growth phase, they were processed with sodium butyrate, 0, 2.5, 5.0, 10.0mmol/L were the concentration, the growth inhibition of MCF was observed. Results The growth rate of MCF-7 cell processed with the sodium butyrate with the Concentration 2.5, 5.0, 10.0mmol/L was significantly slower than that of the parent cell, the growth rate with increasing concentration was slower, there was the significant difference(P < 0.05). The colony efficiency of MCF-7 cells processed with the sodium butyrate with the concentration 5mmol/L was significantly lower than that of the parental cells, there was the significant difference (P < 0.05). After processed with sodium butyrate, Cell G1 was significantly higher than the parental cells, S phase and G2 / M phase were significantly lower than the parental cells, the percentage of apoptotic cells was significantly higher than the parental cells, there was the significant difference(P<0.05). Conclusion Sodium butyrate may be by inducing apoptosis in MCF-7 cells and play a reversal of its role in the malignant behavior.%目的：探讨丁酸钠对乳腺癌细胞MCF-7生长的抑制作用。方法将乳腺癌细胞MCF-7常规培养至对数生长期，采用浓度为0、2.5、5.0、10.0mmol/L的丁酸钠处理后，观察对MCF生长的抑制作用。结果浓度为2.5、5.0、10.0mmol/L的丁酸钠处理的MCF-7细胞生长速度明显慢于亲本细胞，随着浓度的增加呈减慢趋势，差异有统计学意义（P＜0.05）。浓度为5mmol/L的丁酸钠处理后的MCF-7细胞克隆形成率明显低于MCF亲本细胞，差异有统计学意义（P＜0.05）。丁酸钠处理的细胞G1明显高于亲本细胞，S期及G2/M期明显低于亲本细胞，凋亡细胞百分比明显高于亲本细胞，差异有统计学意义（P＜0.05）。结论丁酸钠可能是通过诱导MCF-7细胞凋亡而起到逆转其恶性生物学行为的作用。
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