盐酸纳洛酮治疗急性脑梗死32例临床研究

摘要

目的：探讨盐酸纳洛酮治疗急性脑梗死的临床疗效及安全性。方法选择2014年1月～2015年1月本院采用盐酸纳洛酮治疗的急性脑梗死患者32例临床资料作为观察组进行回顾性分析。另外，选择同期32例采用常规疗法治疗急性脑梗死患者为对照组，对比分析两组临床疗效。结果观察组总有效率为93.75％，明显高于对照组总有效率75.00％，差异具有统计学意义（P＜0.05）。观察组不良反应发生率明显低于对照组，差异具有统计学意义（P＜0.05）。治疗前，两组患者NIHSS与日常生活能力评分无明显差异（P＞0.05），治疗后，两组患者评分均得到了不同程度的改善（P＜0.05），并且观察组评分明显好于对照组，差异有统计学意义（P＜0.05）。结论盐酸纳洛酮治疗急性脑梗死，可明显改善患者神经功能及生活质量，安全有效，值得临床推广。%Objective To investigate the clinical efficacy and safety of naloxone in the treatment of acute cerebral infarction. Methods32 cases of acute cerebral infarction treated by naloxone in our hospital from January 2014 to January 2015 were retrospectively analyzed.32 cases of acute cerebral infarction treated with conventional therapy were selected as the control group.The clinical efficacy of the two groups were compared and analyzed.Results The total effective rate of the observation group was 93.75%,significantly higher than that of the control group 75.00%.The difference was significant,with statistical significance (P<0.05).The adverse reaction rate of observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).Before treatment,the scores of NIHSS and ADL of the two groups were not statistically significant(P>0.05).After treatment, two groups of patients were treated with different degrees of improvement(P<0.05),and the treatment group improved more significantly,there was statistically significant difference(P<0.05).Conclusion Naloxone hydrochloride in the treatment of acute cerebral infarction, can significantly improve the neurological function and quality of life,safe and effective,worthy of clinical promotion.