宫颈炎症患者阴道局部免疫状态与疾病发生的相关性

摘要

目的：探讨分析宫颈炎症患者阴道局部免疫状态与疾病发生的相关性。方法选取我院2013年4月～2014年4月收治的250例宫颈炎症患者，分为淋病奈瑟菌宫颈炎（NG，50例）、人型支原体宫颈炎（MH，50例）、宫颈糜烂患者（EC，50例）、沙眼衣原体宫颈炎（CT，50例）、解脲支原体宫颈炎（UU，50例）和250例正常妇女作为对照组，对所有患者进行阴道灌洗，并应用酶联免疫吸附试验检测洗液中肿瘤坏死因子-α（TNF-α)和白细胞介素-8（IL-8）的水平，其中给予观察组宫颈炎康栓配合射频治疗该病，对照组采用常规射频治疗，对比其疗效和局部免疫状态与疾病发生的相关性。结果阴道灌洗液TNF-α水平，除宫颈糜烂患者（EC）组之外，其余各组均高于对照组，组间比较差异有统计学意义（P＜0.01）。阴道灌洗液IL-8水平，NG组为（336±35）ng/L，MH组为（369±33）ng/L，CT组为（363±31）ng/L，三组和对照组相比，为（314±33）ng/L，（343±35）ng/L及（337±36）ng/L，组间比较差异有统计学意义（P＜0.05）。UU组和EC组与对照组比较差异无统计学意义（P＞0.05）。宫颈炎组治疗总有效率优于对照组（P＜0.05）。结论阴道局部免疫状态在各种宫颈炎症的发病机制中发挥了重要作用，尤其在与疾病发生的相关性中IL-8在人型支原体宫颈炎、沙眼衣原体宫颈炎及淋病奈瑟菌宫颈炎中有更重要的作用。%ObjectiveTo explore and analyze the relevance between part of vagina's immune status and occurrence of disease of patients with cervicitis.Methods250 patients with cervicitis who were admitted to our hospital from April 2013 to April 2014 were allocated into Neisseria gonorrhoeae cervicitis group (NG, 50 patients), Mycoplasma hominis cervicitis group (MH, 50 cases), erosion of cervix group (EC, 50 cases), cervicitis of chlamydia trachomatis group (CT, 50 cases) and urea solution mycoplasma cervicitis group (UU, 50 cases), and 250 healthy women were selected as control group. All patients were received vaginal douche, and enzyme-linked immunosorbent assay was used to detect tumor necrosis factor -α(TNF-α) level and interleukin -8 (IL-8) level in vaginal douche fluid. The observation group was treated with cervicitis suppository combined with radiofrequency ablation, and the control group was treated with conventional radiofrequency ablation. The curative effect and the relevance between part of vagina's immune statues and occurrence of diseases of two groups were compared.Results TNF α levels of all groups except EC group were higher than that of control group, and the comparison among groups was statistically significant (P<0.01). IL-8 levels in vaginal douche fluid of NG group, MH group and CT group were (336±35)ng/L, (369±33)ng/L and (363±31)ng/L respectively, which were compared with those of control group (314±33)ng/L, (343±35)ng/L and (337±36) ng/L. The difference were statistically significant (P<0.05). The comparison between UU group and EC group and control group was not statistically significant (P>0.05). The total effective rate of treatment of cervicitis was better than that of control group (P<0.05).Conclusion The immune status of parts of vagina plays an important role of the pathogenesis of all kinds of cervicitis, especially in relevance with disease occurring in IL-8 in Mycoplasma hominis.