IL-18、TNF-α、VEGF在宫腔粘连患者子宫内膜中的表达及临床意义

摘要

目的：探讨白介素-18（IL-18）、肿瘤坏死因子-α（TNF-α）及血管内皮生长因子（VEGF）在宫腔粘连患者子宫内膜中的表达及临床意义。方法收集我院2010年1月~2013年收治的经宫腔镜检查确诊的宫腔粘连患者80例进行回顾性分析,80例子宫粘连患者中重度粘连者40例，中度粘连者40例，另选择同期行宫腔镜下子宫纵膈切除术的非宫腔粘连患者40例作为对照组，三组患者均采用免疫组化SP法染色检测IL-18、TNF-α及VEGF在子宫内膜组织中的表达。结果重度粘连组子宫内膜中IL-18、TNF-α及VEGF的表达高于对照组及中度粘连组,差异有统计学意义（P＜0.05）；中度粘连组中IL-18、TNF-α及VEGF的表达高于对照组,差异有统计学意义（P＜0.05）。结论白介素-18（IL-18）、肿瘤坏死因子-α（TNF-α）及血管内皮生长因子（VEGF）均参与宫腔粘连的发生发展。%Objective To study the expression and clinical significance of interleukin-18(IL-18), tumor necrosis factor-α(TNF-α), vascular endothelial growth factor (VEGF) on endometrium of patients with intrauterine adhesions. Methods80 patients with intrauterine adhesions, who were treated and diagnosed by hysteroscopy in our hospital from January 2010 to 2013, were selected and retrospectively analyzed, with 40 cases severe adhesion and 40 cases moderate adhesion. Another 40 patients without intrauterine adhesions, who were treated with resection of uterine septa under hysteroscope, were selected as the control group. To test the expression of IL-18, TNF-α, and VEGF on endometrium in the three groups by S-P immunohistochemical staining.Results The expression of IL-18, TNF-α, and VEGF on endometrium in severe adhesion group were higher than which in moderate adhesion group and control group, while which in moderate adhesion group were higher than which in control group, the differences were statically significant(P<0.05).ConclusionIL-18, TNF-α, and VEGF all has partaken in the occurrence and development of intrauterine adhesions.