降钙素原和超敏C反应蛋白在新生儿败血症早期诊断中的意义

摘要

目的：探讨在新生儿败血症早期诊断降钙素原和超敏C反应蛋白的临床意义与价值。方法选取我院2014年1月～2015年1月收治的新生儿败血症患儿共52例作为观察组，选择同期非新生儿败血症患儿共52例作为对照组，收集两组患儿临床资料中降钙素原与超敏C反应蛋白的水平。比较观察组与对照组患儿血清降钙素原与超敏C反应蛋白的水平。结果观察组新生儿败血症患儿血清中降钙素原检测阳性率为84.6%，超敏C反应蛋白检测阳性率为67.3%，明显高于对照组非新生儿败血症患儿降钙素原与超敏C反应蛋白检测阳性率，差异有统计学意义（P＜0.05）。观察组患儿血清降钙素原检测灵敏度为84.6%，特异度为80.8%，均明显高于超敏C反应蛋白灵敏度与特异度，差异有统计学意义（P＜0.05）。结论在新生儿败血症早期，患儿血清中降钙素原与超敏C反应蛋白水平有明显变化，且通过检测降钙素原与超敏C反应蛋白可以作为诊断新生儿败血症的主要依据，降钙素原检测灵敏度与特异度高于超敏C反应蛋白，联合检测二者有助于诊断新生儿败血症。%Objective To explore the clinical significance and value of the early diagnosis of neonatal sepsis with the calcitonin and C reactive protein.MethodsA total of 52 neonatal sepsis patients were treated in our hospital from January 2014 to January 2015 and selected as the observation group,a total of 52 patients with non neonatal sepsis were selected as the control group. The levels of calcitonin and C reactive protein in the clinical data of the two groups were collected. The serum level of calcitonin and C reactive protein in the serum of the two groups were compared.Results In the observation group, the calcitonin and C reactive protein positive rate was 84.6% and 67.3% in the serum of neonatal sepsis, which was significantly higher than that of the control group, the difference was statistically significant(P<0.05). The sensitivity and specificity of serum calcium level in the observation group were 84.6% and 80.8% respectively, which were significantly higher than that of the control group, and the difference was statistically significant(P<0.05).Conclusion In the early stage of neonatal sepsis, the serum levels of calcitonin and C reactive protein had already obvious changed, the main basis for the diagnosis of neonatal sepsis was detected by the expression of calcitonin and C reactive protein. The sensitivity and specificity of calcitonin were higher than those of the high sensitive C reactive protein, and the combined detection of the two index was helpful for the diagnosis of neonatal sepsis.