Objective: To observe the clinical efficacy on combining therapy of Chinese medicine and Western medicine in the treatment of ulcerative colitis. Methods: 100 patients with ulcerative colitis were randomly divided into observation group (50 cases) and control group (50 cases). Control group was given Western medicine treatment [0.5%Metronidazole (100 ml)+Sulfasalazine (2.5 g)] with retention enema; observation group was given combining therapy of Chinese medicine and Western medicine [the Gegen Qinliang Decoction (100 ml)+Sulfasalazine (2.5 g)] with retention enema. The clinical efficacy, stool routinewas and gastroscopy of two groups were compared. Results: After treatment, the clinical efficacy in observation group (94.0%) was significantly higher than that (62.0%) in control group, and the result was statistically significant (x2=14.918, P<0.001). At the follow-up visit for one year of 93 patients, the recurrence rate in observation group (94.0%) was significantly higher than that (62.0%) in control group, and the result was statistically signifi (x2=15.604, P<0.001). And no one had adverse reactions in observation group during the administration. Conclusion: The combining therapy of Chinese medicine and Western medicine in the treatment of ulcerative colitis is safe, more effective, which has fewer adverse reactions and recurrence rate and worthy of clinical application.%目的:观察中西医结合治疗溃疡性结肠炎的临床疗效.方法:将100例确诊为溃疡性结肠炎的患者随机分为对照组(50例)和观察组(50例).对照组给予纯西医治疗方案:0.5%甲硝唑100 ml+柳氮磺吡啶2.5 g,保留灌肠;观察组给予中西医结合治疗方案:葛根芩连汤加减100 ml+柳氮磺吡啶2.5 g,保留灌肠.观察比较两组临床表现、大便常规及内镜检查.结果:观察组治疗总有效率(94.0%)显著高于对照组(62.0%),差异有高度统计学意义(x2=14.918,P<0.001);随访1年,共93例患者获得随访,观察组复发率为10.6%,明显低于对照组的47.8%,两组复发率比较差异有高度统计学意义(x2=15.604,P<0.001),观察组复发率较低.用药期间观察组无一例发生不良反应.结论:中西医联合治疗溃疡性结肠炎疗效确切,不良反应少,复发率低,患者依从性高,值得推广应用.
展开▼
