Composition of single nucleotide polymorphism markers for predicting prognosis of ulcerative colitis in Asians and method for predicting prognosis of ulcerative colitis using the same

摘要

The present invention relates to a single nucleotide polymorphism marker composition for predicting prognosis of ulcerative colitis in Asians and a method for predicting the prognosis of ulcerative colitis using the same. According to the present invention, an analysis in a case is performed using representation data of 587 ulcerative colitis patients (bad prognosis cases of 463 people and good prognosis cases of 124 people) and three independent cohorts-cased HLA fine-mapping data about 1,324 ulcerative colitis patients (bad prognosis cases of 972 people and good prognosis cases of 352 people). Also, modification of rs9268877 SNP related to the prognosis of ulcerative colitis is confirmed. Therefore, according to the present invention, the single nucleotide polymorphism marker composition can be usefully used to perform patient-specific treatment and establish a treatment strategy to diagnose the prognosis of ulcerative colitis.