Objective: To investigate the value of Sodium Bicarbonate in curing secondary hyperpara-thyroidism (SHPT) of patients with chronic renal failure (CFR). Methods: 80 patients with CRF were divided into two groups randomly. Experimental group (40 cases) was given therapy of Sodium Bicarbonate combined with Calcitriol and control group (40 cases) was giv -en Calcitriol only. The serum parathyroid hormone (PTH) was examined every month among the period before therapy and half a year after the therapy. The level of PTH was compared between the two groups, and the compliance rate of PTH which was defined by a target value of 110 ng/L was compared too. Results: The level of PTH between two groups was both descended after therapy, but the rate of decline of experimental group was larger than control group in 1 to 3 month, which made experimental group show lower PTH and higher compliance rate (P<0.05) than control group in the second, third and fourth month. In 5 and 6 month there was no difference of PTH and compliance rate between the two groups. Conclusion: Sodium Bicarbonate Tablets plays a positive role in curing SHPT, which makes PTH reach target value in shorter time.%目的:探讨碳酸氢钠片在治疗慢性肾功能衰竭(CRF)患者继发性甲状旁腺功能亢进(SHPT)中的作用.方法:将80例伴有SHPT的CRF患者随机分为两组,实验组(40例)接受碳酸氢钠和骨化三醇联合治疗,对照组(40例)仅接受骨化三醇治疗.于治疗前和治疗后6个月,每月检测血甲状旁腺激素(PTH).逐月比较治疗后两组患者PTH的水平,以PTH＜110 ng/L为标准,比较两组PTH的达标率.结果:治疗后两组PTH都呈下降趋势,第1～3个月实验组PTH下降速度大于对照组,使得在第2～4个月时实验组PTH小于对照组(P＜0.05),PTH的达标率大于对照组(P＜0.05).5个月和6个月时,两组PTH水平和达标率无差异.结论:口服碳酸氢钠片在SHPT的治疗中具有积极的作用,可以使PTH尽早达到目标值.
展开▼
