更昔洛韦联合金银花颗粒治疗小儿手足口病疗效观察

摘要

目的:观察更昔洛韦联合金银花颗粒治疗手足口病(hand-foot-mouth disease,HFMD)的临床疗效.方法:将154例手足口病患儿随机分为实验组和对照组,每组各77例.实验组采用更昔洛韦联合金银花颗粒治疗,更昔洛韦5 mg/(kg·d) 静脉滴注,每日1次,连续滴注5 d,同时口服金银花颗粒,每日3次(1～3岁患儿每次1 g,4～6岁患儿每次3 g),服用5 d.对照组予以阿昔洛韦15 mg/(kg·d)静脉滴注,每日1次,连续滴注5 d.分别观察实验组和对照组的临床疗效、临床症状消退时间、治疗时间及并发症的发生情况.结果:实验组治疗总有效率为87.01%(67/77),对照组治疗总有效率为67.53%(52/77),差异有统计学意义(P＜0.05).实验组平均退热时间为(1.75±0.41)d,平均皮疹消退时间为(2.98±1.02)d,平均口腔溃疡愈合时间为(3.12±0.86)d,总治疗时间为(4.32±0.87)d.对照组平均退热时间为(2.68±0.53)d,平均皮疹消退时间为(3.87±1.21)d,平均口腔溃疡愈合时间为(4.09±1.42)d,总治疗时间(6.08±1.32)d.实验组平均退热时间、皮疹消退时间、口腔溃疡愈合时间、总治疗时间均低于对照组,差异均有高度统计学意义(均P<0.001).实验组和对照组并发症发生率分别为5.19%和18.18%,差异具有统计学意义(χ2=6.29,P=0.012＜0.05).结论:联合使用更昔洛韦和金银花颗粒治疗手足口病,能够显著减少发热、皮疹、口腔溃疡等症状的持续时间,减少并发症的产生,提高患者治疗疗效.%Objective: To study the clinical efficacy of the combination of Ganciclovir and Honeysuckle in the treatment of children with hand-foot-and-mouth disease (HFMD). Methods: 154 patients were randomly divided into experimental group and control group, each group had 77 cases. The experimental group was treated with the combination of Ganciclovir and Honeysuckle Particles, Ganciclovir was intravenous dripped with 5 mg/(kg · D) a day for five days, while Honeysuckle parti -cles was given by oral, 3 times a day (children aged 1 to 3 per 1 g, 4-6 years old children per 3 g) for 5 days, too. The con -trol group was intravenous dripped with Acyclovir 15 mg/(kg·d) a day, continuous of 5 days. Results: The total effective rate was 87.01% in experimental group and 65.73% in control group, which was significant different (P<0.05). In experimental group, the cooling required time was (1.75±0.41) days, the rash subsided time was (2.98±1.02) days, the oral ulcer healing time was (3.12±0.86) days and total treatment time was (4.32±0.87) days. In control group, the time required for cooling was (2.68±0.53) days, the rash subsided time was (3.87±1.21) days, the oral ulcer healing time was (4.09±1.42) days and the total treatment time was (6.08±1.32) days. The cooling required time, the rash subsided time, the oral ulcer healing time and the total treatment time in experimental group were significantly lower than those in control group with statistical difference (P<0.001). The rate of occurred complications was 5.19% in experimental group and 18.18% in control group with signifi cant difference (χ2=6.29, P=0.012<0.05). Conclusion: The combination of Ganciclovir and Honeysuckle Particles in the treatment of children with HFMD can significantly reduce the fever, rash, mouth ulcers and duration of symptoms, reduce com -plications, and to improve the efficacy of the treatment of patients.