Objective: To provide help for clinical treatnent by investigating the distribution and drug resistance of gramnegative bacteria in our hosptial from 2007 to 2010. Method: 2 840 strains of gram-negative bacteria were isolated from medicine sensitivity training specimens in microbiology laboratory of our hospital from 2007 to 2010. Results: 4 915 strains of pathogenic bacteria were isolated from 2007 to 2010, and gram-negative bacteria was 2 840 strains, which ac counted for 57.78％, the separation rate of escherichia coli was the highest (28.5％). In four consecutive years, the sensitivity of gram-negative bacteria to Imipenem was good, but the drug resistance of escherichia coli and pseudomonas aeruginosa to Aztreonam increased year by year. Conclusion: We should strengthen dynamic monitoring of drug resistance of gram-negative bacteria, in order to provide scientific basis for clinical rational use of antimicrobial drug.%目的:了解我院2007～2010年革兰阴性杆菌的分布和耐药情况,为临床治疗提供帮助.方法:对2007～2010年我院微生物实验室从各种药敏送检标本中培养分离出的革兰阴性杆菌2 840株进行回顾性分析.结果:2007～2010年医院共分离出病原菌4 915株.革兰阴性杆菌2 840株,占57.78%,其中,大肠埃希菌分离率最高(28.5%).连续4年革兰阴性杆菌对亚胺培南敏感性均较好,而大肠埃希菌和铜绿假单胞菌对氨曲南的耐药率均呈逐年上升趋势.结论:应加强革兰阴性杆菌耐药性的动态监测,为临床医师合理使用抗菌药物提供科学依据.
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