双歧杆菌防治极低出生体重儿坏死性小肠结肠炎的作用研究

摘要

目的:观察应用双歧杆菌预防极低出生体重儿坏死性小肠结肠炎(NEC)的有效性.方法:回顾性分析2005年1月～2008年5月在我院NICU住院治疗的生后存活7 d并且开始胃肠道喂养的极低出生体重儿183例的临床资料.结果:预防组NEC发病率为2.10%(2/95),对照组NEC发生率为11.36%(10/88),两组比较差异有统计学意义(P＜0.01).住院期间预防组每日体质量增加(8.108±2.205)g,对照组为(6.256±2.298)g,两组比较差异有统计学意义(P＜0.01).治疗后7 d两组患儿肠道细菌总数、杆菌、球菌总数及杆球菌比值差异均有统计学意义(P<0.01).预防组治疗前、治疗后7 d杆球菌比值差异无统计学意义(P>0.05).治疗前两组患儿大便双歧杆菌数的比较差异均无统计学意义(P＞0.05);治疗后7 d两组患儿大便双歧杆菌数的比较差异有统计学意义(P<0.01).预防组治疗前、治疗后7 d大便双歧杆菌数的比较差异有统计学意义(P<0.01);对照组治疗前、治疗后7 d大便双歧杆菌数的比较差异无统计学意义(P>0.05).结论:给予极低出生体重儿预防性口服双歧杆菌能够降低NEC发病率,促进其体质量增长.其机制与口服双歧杆菌后促进新生儿肠道正常菌群的定植和优势化、维持肠道正常菌群比率有关.%Objective: To observe the preventing effectiveness of applying bifidobacterium to very low birth weight children with NEC. Methods: The clinical data of 183 patients of NICU hospitalization survival 7 d after birth and fed the gastrointestinal tract of very low birth weight children in our hospital from January 2005 to May 2008 were retrospectively analyzed. Results: From the results, the NEC incidence rate of the preventive group was 2.10% (2/95), while the control group was 11.36％ (10/88); the daily weight increase of the preventive group was (8.108±2.205) g, while the control group Was (6.256±2.298) g There were statistical significance in the comparison of both groups (all P