1-己胺甲酰基-5-氟尿嘧啶制备工艺改进

摘要

目的:探讨1-己胺甲酰基-5-氟尿嘧啶的合成并进行工艺改进.方法:以尿素为起始原料,经过醇解、氨解、热分解、最后缩合得到目标产物,反应过程采用薄层层析进行监控.结果:该反应总收率为83.4%.目标产物经紫外光谱、红外光谱、核磁共振及元素分析确证了其化学结构.结论:改进后的工艺原材料价廉易得,反应条件温和,溶剂可回收循环利用,环境污染小,适合工业化生产.%Objective: To improve the synthesis 1-hexylamine formyl-5-fluorouracil. Methods: 1-hexylamine formyl-5-fluorouracil was high effectively synthesized from Urea by alcoholysis with methanol followed by aminolysis wich n-hexylamine and by condensation with 5-Fu. Results: The overall yield was 83.40％. The chemical structures of target product were characterized by UV, IR, NMR and element analysis. Conclusion: This synthetic route is simple and suitable for industrialized production with lower cost, lower pollution and higher yield.