Objective: To study the relationship between hyperhomocysteinemia and carotid artery arteriosclerosis in old cerebral infarction patients. Methods: 150 patients older than 60 years with cerebral infarction were examined by color Doppler ultrasonography. The patients were divided into three groups based on the severity of stenosis of CAA, the moderate severe stenosis group, the slight stenosis group and normal group. 90 cases health examinationers in control group. Hcy level was determined by MEIA. The results of serum Hcy levels in different groups were compared. Results:there were statistically significant differences between the three groups (P＜0.01). There was significant difference of Hcy levels between the slight tenosis group and normal group (P＜0.05). There was statistically significant difference of Hcy level between the cerebral infarction group and control group (P＜0.01). Hcy levels and IMT were positively correlated. Conclusion: serum Hcy level is closely correlated with the severity of the stenosi8 of CAA of cerebral infarction patients. Decreasing the level of serum Hcy may be very important for the treatment and prevention of cerebral infarction patients.%目的:探讨老年脑梗死患者高同型半胱氨酸血症与颈动脉硬化的关系.方法:对150例60岁以上脑梗死患者行颈动脉彩色多普勒超声榆查,根据其检查结果分为内膜正常组、轻度狭窄组和中-重度狭窄组.对照组为90例健康体检者.并运用微粒子酶联免疫分析法测定空腹血浆同型半胱氨酸(Hcy).结果:动脉内膜正常组、轻度颈动脉狭窄组与中-重度狭窄组比较差异均有高度统计学意义(P＜0.01).组间差异比较,颈动脉内膜正常组与轻度狭窄组Hcy水平相比差异有统计学意义(P＜0.05),脑梗死患者Hcy总体平均水平明显高于对照组,差异有高度统计学意义(P＜0.01).直线相关分析显示血浆Hcy水平与内膜中层厚度(IMT)呈正相关.结论:血Hcy水平与老年脑梗死患者颈动脉硬化程度呈正相关,高Hcy血症可能通过加速老年动脉硬化而导致老年脑梗死,如能将二者有机地结合起来,将对老年脑梗死的预防、治疗及判断预后有重要意义.
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