Objective To optimize prescription by using the temperature-sensitive in situ gel with chitosan/glycerophos-phate (GP) matrix as fat-soluble drugs Indapamide (IPM) delivery system, and in vitro evaluation of the physical and chemical properties in this study. Methods IPM chitosan temperature-sensitive in situ gel was prepared by cosolvent-sur-factant combination of technology (the CoSol-Sur technology), and gelation time, gelling morphology and the viscosity of the factors were investigated. Results The cosolvent, the presence of a surfactant TPGS and chitosan could effectively inhibit the IPM for crystal growth. In IPM chitosan/GP system gelling time, with a gelling form, and the viscosity measurement results showed that the presence of a cosolvent and a surfactant could be the system phase transition behavior of formation of the interference effect, wherein the DMAC was stronger than Glycerolformal and Pharmasolve; the Tween 80, Solutol HS15 was stronger than TPGS and Cremphor ELP. Conclusion Cosol-Sur technology can successfully prepare Indapamide chitosan thermosensitive in situ gel.%目的 本研究以壳聚糖/甘油磷酸盐(glycerophosphate,GP)为基质的温敏原位凝胶作为脂溶性药物吲哒帕胺(indapamide,IPM)的载体,并通过其体外理化性质的评价优化处方.方法 通过潜溶-表面活性剂相结合技术(CoSol-Sur技术)制备吲哒帕胺壳聚糖温敏原位凝胶,对原位凝胶胶凝时间、胶凝形态和黏度的影响因素进行考察.结果 对IPM壳聚糖/GP系统胶凝时间与胶凝形态,以及黏度测定结果表明,潜溶剂与表面活性剂的存在均能对体系相转变行为形成干扰效应,其中DMAC强于Glycerolformal、Pharmasolve;Tween 80、Solutol HS15强于TPGS、Cremphor ELP.结论 通过Cosol-Sur技术成功制备吲达帕胺壳聚糖温敏原位凝胶.
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