Objective To discuss the clinical effects of high-dose of Praeetam on patients with cerebral edema after diffuse axonal injury. Methods 96 patients with cerebral after diffuse axonal injury were randomly divided into the control group and the observation group, with 48 cases in each group, the observation group was treated with Praeetam, and the control group was treated with Mannitol, then the clinical effects, imaging findings, drug characteristics and drug safety between the two groups were compared- Results There were no significant differences in the clinical effects, imaging findings, or drug characteristics between the two groups (P ＞ 0.05); but there was a significant difference in the drug safety (P ＜ 0.05 or P ＜ 0.01). Conclusion Praeetam can significantly reduce the volume of cerebral edema, lower the intracranial pressure, and improve the recovery of nerve function, and has high safety.%目的 探讨大剂量吡拉西坦治疗弥漫性轴索损伤后脑水肿的临床疗效.方法 选择弥漫性轴索损伤后脑水肿患者96例,随机分为对照组与观察组,各48例,对照组给予甘露醇治疗,观察组给予吡拉西坦治疗.比较两组患者临床疗效与影像学疗效,对比两种药物作用特点及其不良反应.结果 两组患者在临床疗效与影像学疗效方面均获得显著的效果,且两种药物的特性比较差异无统计学意义(P ＞ 0.05),在对肾脏的毒性反应与安全性方面比较观察组显著优于对照组(P ＜ 0.05或P ＜ 0.01).结论 吡拉西坦可显著减低患者脑水肿体积,降低颅内压,促进患者神经功能的恢复,且具有较高的安全性.
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