Suvivin和VEGF在前列腺癌组织中的表达及相关性研究

摘要

目的 通过检测前列腺增生(BPH)和前列腺癌(PCa)组织中Survivin和VEGF的表达情况,分析Survivin和VEGF表达与前列腺癌组织Gleason评分、肿瘤转移的关系及二者之间的相互关系.方法 应用免疫组化SP法检测20例BPH和40例PCa组织中Survivin及VEGF的表达情况以及二者在PCa不同病理分级、远处骨转移中的表达情况.结果 PCa组织中Survivin及VEGF的表达情况分别为87.5%和90.0%,二者与BPH组织相比,差异有统计学意义(P<0.05).Survivin在中低评分组(中、高分化)PCa及高评分组(低分化)PCa中的表达阳性率分别为65.O%和95.0%,差异有统计学意义(P<0.05);VEGF的表达率分别为70.0%和100.0%,差异有统计学意义(P<0.05).Sur-vivin在伴全身骨转移、非骨转移两组中的表达阳性率分别为87.6%和44.0%,差异有统计学意义(P<0.05).VEGF的阳性表达率分别为72.O%和93.3%,差异有统计学意义(P<0.05).Survivin与VEGF在PCa中的表达呈正性相关(r=0.378,P=0.017<0.05).结论 Survivin及VEGF的表达与PCa病理分级、骨转移密切相关,检测Survivin及VEGF的表达可以判断PCa的进展及预后情况,且Survivin和VEGF在PCa的发生、发展中存在协同作用.%Objective Through delecting the expression of inhibitor of Survivin and VEGF In prostate carcinoma (PCa) and benign prostate hyperplasia (BPH) tissue, to analyze the relationship of Survivin and VEGF gene expression and Gleason score, clinical stage in prostate cancer. Methods The expression of Survivin and VEGF in the tissue of 20 BPH and 40 PC a was detected, the expression in different pathological grades and with bone or non-bone metastasis of prostate cancer with Immunohlstochemistry. Results The expression of Survivin and VEGF in PCa were 87.5% and 90.0%, there was a significant difference (P ＜ 0.05). The expression of Survivin in lower-middle-score and high PCa group were 65.0% and 95.0% respectively, there was a significant difference (P ＜ 0.05); the expression of VEGF were 70.0% and 1 00.0% respectively, there was a significant difference (P ＜ 0.05). The expression of Survivin In the group with bone metastasis and non-Bone metastasis were 87.6% and 44.0%, there was a significant difference (P ＜ 0.05). The expression of VEGF were 72.0% and 93.3%, there was a significant difference (P ＜ 0.05). The expression of Survivin and VEGF were positively correlated In PCa (r - 0.378,P = 0.017 ＜ 0.05). Conclusion The expression of Survivin and VEGF are closely related to the pathological grade and distant bone metastasis, so the detection of Survivin and VEGF can provide the basis for the judgment of prostate cancer progression and prognosis. Survivin and VEGF play synergetic roles In the occurrence and development of PCa.