Objective To investigate the effect of Losartan on serum uric acid (UA) and glomerular filtration rate (GFR) in patients with essential hypertension. Methods 80 patients with essential hypertension were randomly divided into Losartan group (Losartan 50 mg, 40 cases) and control group (Benazepril 10 mg, 40 cases). Total treatment duration was 8 weeks, serum uric acid levels and renal function were measured before and after treatment, and the glomerular filtration rate was calculated. Results The level of blood pressure of two groups were significantly lower than before treatment (P < 0.05), the antihypertensive effect in the two groups were not significant different (P > 0.05). After 8 weeks of treatment, serum UA levels of Losartan group were significantly lower than before treatment (P < 0.05), and compared with the control group, the difference was significant (P < 0.05). After 8 weeks treatment, GFR than those before treatment of all the patients were significantly increased (P < 0.05), but there were no significant differences between the two groups (P > 0.05). Conclusion Losartan and Benazepril all have a good antihypertensive and renal protective effect, but Losartan can reduce the uric acid.%目的 探讨氯沙坦对原发性高血压患者的降压疗效以及对血清尿酸(UA)及肾小球滤过率(GFR)的影响.方法 选取原发性高血压患者80例随机分成氯沙坦组(氯沙坦钾片50 mg,40例)和对照组(贝那普利片10 mg,40例).总疗程共8周,治疗前后分别测血UA水平及肾功能,计算GFR.结果 两组患者血压与治疗前比较均显著降低(P ＜ 0.05),两组降压效果无显著差异(P ＞ 0.05).氯沙坦组治疗8周后血清UA水平与治疗前比较显著降低(P ＜ 0.05),与对照组比较差异有统计学意义(P ＜ 0.05).两组患者治疗8周后GFR均较治疗前显著升高(P ＜ 0.05),但组间比较差异无统计学意义(P ＞ 0.05).结论 氯沙坦和贝那普利均有具有良好的降压效果和肾脏保护作用,但氯沙坦在肾脏保护的同时独有降低UA的作用.
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