虎驹乙肝胶囊与阿德福韦酯联合治疗慢性乙型肝炎临床观察

摘要

目的 观察虎驹乙肝胶囊与阿德福韦酯联合治疗慢性乙型肝炎(慢乙肝)患者血清肝纤维化的作用.方法 92例慢乙肝患者随机分为两组,治疗组46例,给予口服虎驹乙肝胶囊5粒,每日3次,口服阿德福韦酯10mg1日1次.对照组46例,口服阿德福韦酯10 mg 1日1次,疗程1年.治疗1年观察指标.结果 治疗组治疗前后血清透明质酸(HA)、四型胶原(CⅣ)、三型胶原(PCⅢ)和层粘连蛋白(LN)四项指标比较,差异有统计学意义(P＜0.05).治疗组与对照组治疗后HA、CⅣ、PCⅢ、LN比较差异有统计学意义(P＜0.05).结论 两药合用1年,能显著改善慢乙肝患者血清肝纤维化指标,有助于加强中西医结合抗肝纤维化治疗.%Objective To observe the effect of Huju Hepatitis B Capsule in combination with Adefovir Dipivoxil on serum hepatic fibrosis of patients with chronic hepatitis B. Methods 92 cases with chronic hepatitis B were randomly divided into two groups, There were 46 patients in the treatment group in which the therapy was five Huju Hepatitis B Capsule three times daily in combination with Adefovir Dipivoxil 10 mg once daily, while Adefovir Dipivoxil 10 mg once daily treatment for 1 year in the control group with 46 cases. Results Serum levels of hyaluronic acid treatment (HA), collagen]V (C Ⅳ) ,collagen HI (PC M), and laminin protein (LN) were observed before and after treatment, year of treatment as the treatment observed, there were significant differences (P < 0.05) before and after treatment in treatment group. After treatment, there were also significant differences (P < 0.05) in the two groups. Conclusion Combination with the two drugs for one year, it can significantly improve serum fibrosis markers in patients with chronic hepatitis B.