Adefovir dipivoxil having a new crystal form, preparation method thereof, and compositon for preventing or treating chronic hepatitis B containing the same as an active ingredient

摘要

The present invention relates to a new crystal form , their preparation and their use of adefovir Diffie acid , more particularly it is Cu in an X-ray diffraction pattern of the target radiation , the main characteristic peak indicated by the 2 3.3 0.1 and 6.6 Diffie of adefovir acid comprising a characteristic peak appearing at 0.1 new crystal form , its preparation method and containing the same as an active ingredient relates to a composition for the prevention or treatment of chronic hepatitis B infection . High and new crystal forms of adefovir Diffie acid according to the invention is stable , and the production method used in the reproducibility and hyeonjangseong , high yield and at least 90% , 99% can be produced in a new crystalline form of high purity adefovir Diffie acid , chronic can be useful in the prevention or treatment of hepatitis B . ;