我院248例药品不良反应报告分析

摘要

目的 了解我院药品不良反应(ADR)发生的特点,为临床合理用药提供依据.方法对2008～2011年我院上报的248例ADR报告按患者年龄、性别、给药途径、药品类别、ADR累及器官或系统及临床表现进行统计分析.结果 ADR发生率最高的是抗菌药物,占40.73%;60岁以上老年患者ADR发生率较高,占31.05%;静脉给药是导致ADR的主要因素,占88.31%;ADR临床表现以皮肤及其附件损害最为常见,占35.48%.结论应重视ADR监测工作,强化ADR监测意识,确保临床安全有效、合理规范用药,最大程度的保证患者用药安全.%Objective To understand the characteristics of adverse drug reactions (ADR) in our hospital, in order to provide basis for rational drug use in clinic. Methods A total of 248 ADR patients were collected in our hospital from 2008 to 2011. The age and sex of patients, route of administration, drug varieties, involved organs or systems and the clinical manifestations of the ADR reports were analyzed statistically. Results Among all durgs, the ADR incidence of anti-infection drugs was the highest, which was accounted for 40.73%; among 248 ADR patients, the ADR incidence of over 60 years old patients was the highest, which was accounted for 31.05%; intravenous injection was the major factor which caused of ADR, it was accounted for 88.31%; the commonest clinical symptoms of ADR were lesions on the skin and its annexes, which was accounted for 35.48%. Conclusion ADR monitoring work and monitoring consciousness should be emphasized, in order to ensure clinical rational drug administration and the safety of patients.