Objective To investigate therapy efficacy of Sijunzi Decoction combined with Yinzhihuang Oral Liquid in the treatment of neonates with hyperbilirubinemia after asphyxia. Methods 56 neonates with hyperbilirubinemia after asphyxia were randomly divided into treatment group (28 cases) which treated by Sijunzi Decoction combined with Yinzhihuang Oral Liquid and conventional treatment control group (28 cases). The control group was given the intermittent blue light irradiation, the patients with bilirubin increasing fast or high levels were given treatment of correct acidosis, intravenous drip of liver enzyme inducer and albumin, symptomatic and supportive treatment, such as oxygen, resistance to infection, the intravenous nutrition and the other conventional treatment methods. The treatment group was treated by routine treatment combined with Sijunzi Decoction enema and Yinzhihuang Oral Liquid. The two groups would be checked total bilirubin of serum before treatment, the diversification of bilirubin each day and the days of the serum bilirubin which decreases to 102 μmol/L would be monitored by transcutaneous bilirubin monitor during the treatment. Results There was no significant difference in serum bilirubin before treatment in the two groups (P > 0.05); there were statistically significant differences in the decrease of the daily average of bilirubin between the treatment group that treated by Sijunzi Decoction combined with Yinzhihuang Oral Liquid and the control group (P < 0.05); the comparison of bilirubin <102 μmol/L days between the treatment group that treated by Sijunzi Decoction combined with Yinzhihuang Oral Liquid and the control group showed statistically significant difference (P < 0.05); the Sijunzi Decoction combined with Yinzhihuang Oral Liquid in treatment group markedly effective in 22 cases (78.57%) was significantly higher than that of control group, which markedly effective in 10 cases (35.72%), the apparent effective rate of two groups showed statistically significant differences (P < 0.05); the total effective rate of 92.86% that treated by Sijunzi Decoction combined with Yinzhihuang Oral Liquid was significantly higher than the total effective rate of 75.00% in control group, there was significant difference on the total efficiency between the two groups (P < 0.05). Conclusion The number of days which daily bilirubin values and serum bilirubin values that treated by Sijunzi Decoction combined with Yinzhihuang Oral Liquid in asphyxia of newborn hyperbilirubinemia decreased to 102 μmol/L is better than conventional treatment, it is worthy of clinical promotion.%目的 探讨四君子汤联合茵栀黄治疗新生儿窒息后高胆红素血症的疗效.方法 将华北石油总医院新生儿窒息后高胆红素血症56例分为治疗组(28例)和对照组(28例),对照组采用间隙蓝光照射,胆红素上升快或水平高者给予纠酸、肝酶诱导剂、白蛋白静脉滴注,对症及支持治疗,如供氧、抗感染、静脉营养等常规治疗方法.治疗组在常规治疗方法 的基础上加用四君子汤灌肠、茵栀黄口服.两组治疗前检查血清总胆红素,治疗期间应用经皮胆红素监测仪监测每日胆红素变化,同时监测血清胆红素值下降至102 μmol/L的天数.结果 两组治疗前血清胆红素值无统计学意义(P > 0.05);治疗组日均胆红素下降值与对照组比较差异有统计学意义(P < 0.05); 治疗组胆红素<102 μmol/L天数与对照组比较差异有统计学意义(P < 0.05);治疗组显效22例(78.57%)明显高于对照组显效10例(35.72%),两组显效率比较差异有统计学意义(P < 0.05);治疗组总有效率(92.86%)明显高于对照组总有效率(75.00%),两组总有效率比较差异有统计学意义(P < 0.05).结论 四君子汤联合茵栀黄治疗新生儿窒息后高胆红素血症日均胆红素下降值、血清胆红素值下降至102 μmol/L的天数优于常规治疗,值得临床推广.
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