抗抑郁药潜在作用靶点-神经营养因子和神经发生

摘要

抗抑郁药已在临床上应用了几十年,然而直到现在抗抑郁药的作用机制还不清楚.越来越多的研究表明抗抑郁治疗能够增加神经营养因子的表达水平和调节海马内神经发生,并且抗抑郁药能够逆转神经紧张导致的脑内神经营养因子表达下调和海马内神经发生下调.同时,抗抑郁药的作用又受神经营养因子表达水平和神经发生的调节.因此,调节脑内神经营养因子表达水平和海马神经发生可能是抗抑郁药新的、有效的作用靶点.%Antidepressants has been applied for the treatment of depression for decades. Until now, however, the mechanisms underlying the therapeutic efficacy of antidepressants remain unknown. A growing body of research supports that antidepressants can increase the neurotrophic factor expression and neurogenesis in the hippocampus. Furthermore, antidepressants block or reverse stress—induced downregulation of neurotrophic factor expression in brain and neurogenesis in the hippocampus. At the same time, the therapeutic efficacy of antidepressants require neurotrophic factor and neurogenesis. Thus, the regulation of neurotrophic factor expression in the brain and neurogenesis in the hippocampus may provide additional targets for the development of novel, more efficacious antidepressant drugs.