载脂蛋白E基因多态性与颈动脉粥样硬化相关性的研究进展

摘要

Hiperlipidemia and carotid atherosclerosis are important risk factors of cerebrovascular disease. Studies find that apolipoprotein E in plasma can regulate lipid metabolism to maintain the metabolism of cholesterol, closely related to the blood lipid level and the progress of carotid atherosclerosis. Apolipoprotein E gene is polymorphism, dif-ferent allele can influnce the blood lipid and carotid atherosclerosis in different degree, has important significance on occurrence, development, prognosis and prevention of cerebral-vascular disease. The relationship between apolipopro-tein gene polymorphisms and hyperlipidemia and carotid atherosclerosis are summarized, and review the advances in gene therapy research in this field in recent years.%高血脂及颈动脉粥样硬化是脑血管疾病的重要危险因素。研究发现血浆中的载脂蛋白E可以调节脂质代谢过程，并维持胆固醇代谢平衡，与血脂水平及颈动脉粥样硬化的进展密切相关。载脂蛋白E基因存在多态性，不同的等位基因对血脂水平及颈动脉粥样硬化的影响不同，对脑血管病的发生、发展、预后判断以及二级预防均有重要意义。本文对载脂蛋白基因的多态性、其与高脂血症及颈动脉粥样硬化之间的关系进行总结，并对近年来国内外关于这一领域的基因治疗研究进展进行综述。