Dermol与E-cadherin在喉鳞状细胞癌组织中的表达及其相关性研究

摘要

目的：探讨喉鳞状细胞癌组织中Dermol与E-cadherin的表达及其相关性。方法应用免疫组化SP法检测Dermol与E-cadherin在48例喉鳞癌组织及30例癌旁正常组织中的表达情况,分析它们在不同组织中的相互关系及与喉鳞癌临床参数的关系。结果 Dermol、E-cadherin在喉鳞癌及癌旁正常组织中的阳性表达率比较,差异均有高度统计学意义(P<0.01)；不同淋巴结转移及临床分期情况的喉鳞状细胞癌组织中Dermol、E-cadherin的阳性表达率比较,差异均有统计学意义(P<0.01或P<0.05)；不同年龄的喉鳞状细胞癌组织中Dermol、E-cad-herin的阳性表达率比较,差异无统计学意义(P跃0.05)。喉鳞状细胞Dermol的阳性表达与E-cadherin的阳性表达呈负相关(r=-0.344,P<0.05)。结论 Dermol与E-cadherin在喉鳞状细胞癌发生、分化程度、浸润及转移过程中的起重要作用,Dermol与E-cadherin的协同作用可能影响喉鳞状细胞癌的浸润和转移。%Objective To investigate the expression and clinical significances of Dermol and E-cadherin in laryngeal squamous cell carcinoma (LSCC). Methods The expression of Dermol and E-cadherin was detected by immunohisto-chemistry SP method in 48 tissues of LSCC and 30 tissues of tumor-adjacent normal. The relationship between two fac-tors and clinical pathological features of LSCC was investigated. Results The differences of the positive rate of Dermol and E-cadherin in tissues of LSCC and tumor-adjacent normal were statistically significant (P< 0.01); the positive ex-pression rate of Dermol and E-cadherin in different status of lympha node metastasis, clinical stage in LSCC was statis-tical significant different (P < 0.01 or P < 0.05); but no statistically significant difference between the different age groups (P> 0.05). The positive expression of Dermol was negatively related to that of E-cadherin (r = -0.344, P<0.05). Conclusion Dermol and E-cadherin play an important role in the occurrence, degree of differentiation, infiltra-tion and metastasis of laryngeal squamous cell carcinoma. The synergistic effect of Dermol and E-cadherin may have some effects on the infiltration and metastasis of laryngeal carcinoma.