腹腔镜联合活血化瘀汤对轻型子宫内膜异位症不孕患者的疗效及对机体氧化应激状态的影响

摘要

目的：研究分析腹腔镜合并活血化瘀汤对于轻型子宫内膜异位症不孕患者的疗效以及对机体氧化应激状态的影响。方法选择2012年5月~2014年5月东莞市南城医院诊治的轻型子宫内膜异位症不孕患者98例为研究对象,将其随机分成观察组及对照组,每组各49例。观察组患者给予腹腔镜联合活血化瘀汤治疗；对照组给予腹腔镜手术治疗。比较两组患者的疗效及对机体氧化应激状态的影响。结果治疗后,观察组单核细胞趋化蛋白-l(MCP-1)以及活化调节因子(RANTES)水平分别为(141.33±42.61)ng/L和(235.18±90.38)μg/L,对照组MCP-1以及RANTES水平分别为(177.37±48.78)ng/L和(411.67±130.95)μg/L,两组均得到有效缓解,与治疗前比较,差异均有高度统计学意义(P<0.01),且治疗后观察组MCP-1及RANTES水平均明显低于对照组,差异均有高度统计学意义(P<0.01)。治疗后,观察组8-异前列腺素F2α(8-ios-PGF2α)以及谷胱甘肽过氧化物酶(GSH-Px)水平分别为(153.49±9.73)ng/mL和(310.86±11.67)U/L,对照组8-ios-PGF2α及GSH-Px水平分别为(177.37±48.78)ng/mL和(411.67±130.95)U/L,两组均得到有效缓解,与治疗前比较,差异均有统计学意义(P<0.05或P<0.01),且治疗后观察组8-ios-PGF2α水平明显低于对照组,GSH-Px水平明显高于对照组,差异均有高度统计学意义(P <0.01)。观察组显效率为67.35%,明显高于对照组的42.86%,差异有统计学意义(P<0.05)。结论使用腹腔镜合并活血化瘀汤对轻型子宫内膜异位症不孕患者进行治疗,有效提升治疗效果,缓解患者机体氧化应激状态。%Objective To study and analyze the effect and influence on oxidative stress status of aparoscopy combined with Huoxuehuayu Decoction for patients with mild endometriosis infertility. Methods 98 cases of patients with mild endometriosis infertility hospitalized from May 2012 to May 2014 in Nancheng Hospital of Dongguan were randomly di-vided into two groups, with 49 cases in each group. Patients of the observation group were given laparoscopy combined with Huoxuehuayu Decoction, and patients of the control group were given laparoscopic operation only. The clinical ef-fect and oxidative stress status between two groups were compared. Results After treatment, monocyte chemoattractant protein-l (MCP-1) and activation of regulatory factor (RANTES) levels of the observation group were (141.33±42.61) ng/L and (235.18±90.38)μg/L respectively, and those of the control group were (177.37±48.78) ng/L and (411.67±130.95)μg/L respectively, both groups were alleviated effectively, compared with before treatment, the differences were statisti-cally significant (P< 0.01), and levels of MCP-1 and RANTES of the observation group were significantly lower than those of the control group (P<0.01). After treatment, levels of 8-iso prostaglandin F2 alpha (8-ios-PGF2 alpha) and glutathione peroxidase (GSH-Px) in the observation group were (153.49±9.73) ng/mL and (310.86±11.67) U/L respec-tively, and those of the control group were (177.37±48.78) ng/mL and (411.67±130.95) U/L respectively, both groups were relieved effectively, compared with before treatment, the differences were statistically significant (P<0.05 or P<0.01). After treatment, level of 8-ios-PGF2α in the observation group was significantly lower than that of the controlgroup, level of GSH-Px was significantly higher than that of the control group, the differences were statistically signifi-cant (P<0.01). The significant efficiency of the observation group was 67.35%, was significantly higher than that of the control group (42.86%), and the difference was statistical significance (P< 0.05). Conclusion Using laparoscopy com-bined with Huoxuehuayu decoction to treat patients with mild endometriosis infertility can effectively enhance the treat-ment effect and relieves oxidative stress state.