冠心病患者血浆B型钠尿肽前体及超敏C反应蛋白水平的检测及意义

摘要

Objective To investigate the changes and clinical significance of plasma pro-BNP and hs-CRP in patients with coronary heart disease. Methods One hundred cases with coronary heart disease from June 2013 to June 2014 in the First Affiliated Hospital of Hebei North University ("our hospital" for short) were selected and divided into SAP group (29 cases), UAP group (41 cases), AMI group (30 cases) according to the clinical type and single vascular lesion group (32 cases), double vascular lesion group (35 cases), three or more lesion group (33 cases) according to the number of coronary vascular lesions. Thirty cases of physical examination in the same term in our hospital were chose as healthy control group. pro-BNP and hs-CRP level were detected, Gensini scoring method was used to quantize the pathological changes of coronary blood vessels. Results ①The pro-BNP and hs-CRP level in SAP group were higher than those in healthy control group, the pro-BNP and hs-CRP level and Gensini score in UAP group were all higher than those in SAP group, the pro-BNP and hs-CRP level and Gensini score in AMI group were all higher than those in UAP group, the differences were statistically significant (P<0.05).②The pro-BNP and hs-CRP level and Gensini score in double vascular lesion group and three or more lesion group were all higher than those in single vascular lesion group, the differences were statistically significant (P<0.05). The pro-BNP and hs-CRP level and Gensini score in three or more lesion group were all higher than those in double vascular lesion group, the differences were statistically significant (P<0.05).③The positive correlation relationship of pro-BNP, hs-CRP level and Gensini score were found in SAP group, UAP group, AMI group (P<0.05). The positive correlation relationship of pro-BNP, hs-CRP level and Gensini score were found in single vascular lesion group, double vascular lesion group, three or more lesion group (P< 0.05). Con-clusion The lesion grade of coronary heart disease has correlation relationship with pro-BNP, hs-CRP level, it can re-flect the degree of myocardial damage.%目的：探讨不同类型及程度冠心病患者血浆B型钠尿肽前体(pro-BNP)及超敏C反应蛋白(hs-CRP)水平的变化及临床意义。方法选择2013年6月~2014年6月在河北北方学院附属第一医院(以下简称“我院”)确诊的冠心病患者100例，按临床类型分为稳定型心绞痛(SAP)组29例(SAP组)，不稳定型心绞痛(UAP)组41例(UAP组)，急性心肌梗死(AMI)组30例(AMI组)；按照冠脉血管病变的数目，将患者分为单支病变组32例、双支病变组35例、三支及以上病变组33例；另选择同期在我院行健康体检者30例为健康对照组。检测各组pro-BNP及hs-CRP水平，采用Gensini评分法对病变的冠脉血管给予量化评分。结果①SAP组pro-BNP、hs-CRP水平明显高于健康对照组，UAP组pro-BNP、hs-CRP水平及Gensini评分明显高于SAP组，AMI组pro-BNP、hs-CRP水平及Gensini评分明显高于UAP组，差异均有统计学意义(P<0.05)。②双支病变组、三支及以上病变组pro-BNP、hs-CRP水平及Gensini评分均高于单支病变组，差异均有统计学意义(P<0.05)。三支及以上病变组pro-BNP、hs-CRP水平及Gensini评分均高于双支病变组，差异均有统计学意义(P<0.05)。③pro-BNP、hs-CRP水平分别与SAP组、UAP组和AMI组的Gensini评分呈正相关关系(P<0.05)。 pro-BNP、hs-CRP水平分别与单支病变组、双支病变组、三支及以上病变组的Gensini评分呈正相关关系(P<0.05)。结论冠心病病变程度与pro-BNP及hs-CRP水平间具有相关性，可以用来反映心肌受损的程度。