白藜芦醇在癫痫治疗中的研究进展

摘要

癫痫是慢性反复发作性疾病，有20%~30%的癫痫患者经正规的抗癫痫治疗后癫痫发作仍不能得到有效控制。癫痫的发病机制复杂，目前的抗癫痫药物均有一定的不足之处或副作用较大。白藜芦醇是一种多效的植物抗毒素，对癫痫具有一定的治疗作用。其抗癫痫的机制包括了抑制异常放电、减轻癫痫发作后炎性反应，对抗癫痫发作诱导的细胞凋亡及神经元的保护作用。%Epilepsy is a chronic, recurrent paroxysmal disease. About 20%-30% of epilepsy patients cannot be effec-tively controlled after rational therapy. Epilepsy pathogenesis complex and the antiepileptic drugs have certain short-comings and some side effects. Resveratrol is a pleiotropic phytoalexin, which has a certain effect on epilepsy treat-ment. The antiepileptic mechanism of resveratrol includes inhibitting the abnormal discharge of epilepsy, reducing the inflammatory reaction after seizure, playing the antagonistic role on cell apoptosis induced by seizure and protective ef-fects on neurons.