Sestrin2抗氧化应激作用在缺血再灌注中的研究进展

摘要

Sestrin2是一种高保守、应激诱导抑制雷帕霉素靶蛋白的重要蛋白分子.作为P53调节哺乳动物雷帕霉素靶蛋白信号通路抗氧化应激作用的一种重要蛋白分子,Sestrin2可以激活磷酸腺苷依赖蛋白激酶蛋白并磷酸化结节性硬化复合物,进而抑制哺乳动物雷帕霉素靶蛋白,可减轻组织因缺血再灌注导致的损伤.近几年,国内外对Sestrin2蛋白分子的研究已有很大的进展,本文就近几年Sestrin2抗氧化应激作用研究进展以及其可能的临床应用进行综述.%Sestrin2 is a highly conserved,stress-inducible protein.As a important protein for P53-regulated mammalian target of rapamyein complex (mTORC1) signaling pathway,Sestrin2 activates AMP activated protein kinase (AMPK) and target it to phosphorylate tuberous seleresis complex (TSC2),thereby inhibiting mTORC1,reducing the ischemia-reperfusion injury.In recent years,there are great progress in the studis of Sestrin2.This paper reviews the role of Sestrin2 in anti-oxidative stress and the potential clinical application as a therapeutic target to prevent/treat related diseases.